Abstract

In today’s world, Parkinson’s disease (PD) has been introduced as a long-term degenerative disorder of the central nervous system which mainly affects approximately more than ten million people worldwide. The vast majority of diagnostic methods for PD have operated based on conventional sensing platforms, while the traditional laboratory tests are not efficient for diagnosis of PD in the early stage due to symptoms of this common neurodegenerative syndrome starting slowly. The advent of the aptasensor has revolutionized the early-stage diagnosis of PD by measuring related biomarkers due to the myriad advantages of originating from aptamers which can be able to sensitive and selective capture various types of related biomarkers. The progress of numerous sensing platforms and methodologies in terms of biosensors based on aptamer application for PD diagnosis has revealed promising results. In this review, we present the latest developments in myriad types of aptasensors for the determination of related PD biomarkers. Working strategies, advantages and limitations of these sensing approaches are also mentioned, followed by prospects and challenges.

摘要

在当今世界，帕金森病 (PD) 已被介绍为一种中枢神经系统的长期退行性疾病，主要影响全球约 1000 万人。PD的绝大多数诊断方法都是基于传统的传感平台进行操作的，而传统的实验室测试由于这种常见的神经退行性综合征的症状起效缓慢，因此在早期诊断PD时效率不高。适体传感器的出现彻底改变了通过测量相关生物标志物对 PD 的早期诊断，因为适体来源的无数优点可以灵敏和选择性地捕获各种类型的相关生物标志物。许多传感平台和方法在基于适配体应用的 PD 诊断生物传感器方面的进展已经显示出有希望的结果。在这篇综述中，我们介绍了用于确定相关 PD 生物标志物的各种适体传感器的最新进展。还提到了这些传感方法的工作策略、优点和局限性，然后是前景和挑战。