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POLYRETINA restores light responses in vivo in blind Göttingen minipigs
Nature Communications ( IF 16.6 ) Pub Date : 2022-06-27 , DOI: 10.1038/s41467-022-31180-z
Paola Vagni 1 , Marta Jole Ildelfonsa Airaghi Leccardi 1 , Charles-Henri Vila 1 , Elodie Geneviève Zollinger 1 , Golnaz Sherafatipour 1 , Thomas J Wolfensberger 2 , Diego Ghezzi 1
Affiliation  

Retinal prostheses hold the potential for artificial vision in blind people affected by incurable diseases of the outer retinal layer. Available technologies provide only a small field of view: a significant limitation for totally blind people. To overcome this problem, we recently proposed a large and high-density photovoltaic epiretinal device, known as POLYRETINA. Here, we report the in vivo assessment of POLYRETINA. First, we characterise a model of chemically-induced blindness in Göttingen minipigs. Then, we develop and test a minimally invasive injection procedure to insert the large epiretinal implant into the eye. Last, we show that POLYRETINA restores light-evoked cortical responses in blind animals at safe irradiance levels. These results indicate that POLYRETINA holds the potential for artificial vision in totally blind patients affected by retinitis pigmentosa.



中文翻译:

POLYRETINA 恢复盲人哥廷根小型猪体内的光反应

视网膜假体为受视网膜外层无法治愈疾病影响的盲人提供人工视觉的潜力。现有技术只能提供很小的视野:对于完全失明的人来说是一个重大限制。为了克服这个问题,我们最近提出了一种大型高密度光伏视网膜前装置,称为 POLYRETINA。在这里,我们报告了 POLYRETINA 的体内评估。首先,我们描述了哥廷根小型猪的化学致盲模型。然后,我们开发并测试了一种微创注射程序,将大的视网膜前植入物插入眼睛。最后,我们展示了 POLYRETINA 在安全辐照度水平下恢复盲人动物的光诱发皮层反应。

更新日期:2022-06-27
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