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A structural and functional subdivision in central orbitofrontal cortex
Nature Communications ( IF 16.6 ) Pub Date : 2022-06-24 , DOI: 10.1038/s41467-022-31273-9
Maya Zhe Wang 1, 2 , Benjamin Y Hayden 1, 2 , Sarah R Heilbronner 1
Affiliation  

Economic choice requires many cognitive subprocesses, including stimulus detection, valuation, motor output, and outcome monitoring; many of these subprocesses are associated with the central orbitofrontal cortex (cOFC). Prior work has largely assumed that the cOFC is a single region with a single function. Here, we challenge that unified view with convergent anatomical and physiological results from rhesus macaques. Anatomically, we show that the cOFC can be subdivided according to its much stronger (medial) or weaker (lateral) bidirectional anatomical connectivity with the posterior cingulate cortex (PCC). We call these subregions cOFCm and cOFCl, respectively. These two subregions have notable functional differences. Specifically, cOFCm shows enhanced functional connectivity with PCC, as indicated by both spike-field coherence and mutual information. The cOFCm-PCC circuit, but not the cOFCl-PCC circuit, shows signatures of relaying choice signals from a non-spatial comparison framework to a spatially framed organization and shows a putative bidirectional mutually excitatory pattern.



中文翻译:

中央眶额皮质的结构和功能细分

经济选择需要许多认知子过程,包括刺激检测、评估、运动输出和结果监测;许多这些子过程与中央眶额皮质(cOFC)有关。先前的工作在很大程度上假设 cOFC 是具有单一功能的单一区域。在这里,我们用恒河猴的解剖学和生理学结果来挑战这一统一观点。在解剖学上,我们表明 cOFC 可以根据其与后扣带皮层 (PCC) 更强(内侧)或更弱(外侧)的双向解剖连接进行细分。我们分别称这些子区域为 cOFC m和 cOFC l。这两个子区域具有显着的功能差异。具体来说,cOFC m显示与 PCC 的增强功能连接,如尖峰场相干性和互信息所示。cOFC m -PCC 电路,而不是 cOFC l -PCC 电路,显示了将选择信号从非空间比较框架中继到空间框架组织的特征,并显示出假定的双向相互兴奋模式。

更新日期:2022-06-24
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