Background

Lycopene is a natural red compound with potent antioxidant activity that can be utilized both as pigment and as a raw material in functional food, and so possesses good commercial prospects. The biosynthetic pathway has already been documented, which provides the foundation for lycopene production using biotechnology.

Aim of review

Although lycopene production has begun to take shape, there is still an urgent need to alleviate the yield of lycopene. Progress in this area can provide useful reference for metabolic engineering of lycopene production utilizing multiple approaches.

Key scientific concepts of review

Using conventional microbial fermentation approaches, biotechnologists have enhanced the yield of lycopene by selecting suitable host strains, utilizing various additives, and optimizing culture conditions. With the development of modern biotechnology, genetic engineering, protein engineering, and metabolic engineering have been applied for lycopene production. Extraction from natural plants is the main way for lycopene production at present. Based on the molecular mechanism of lycopene accumulation, the production of lycopene by plant bioreactor through genetic engineering has a good prospect. Here we summarized common strategies for optimizing lycopene production engineering from a biotechnology perspective, which are mainly carried out by microbial cultivation. We reviewed the challenges and limitations of this approach, summarized the critical aspects, and provided suggestions with the aim of potential future breakthroughs for lycopene production in plants.

中文翻译：

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天然红色素番茄红素生产工程的进展：从生物技术角度进行的系统回顾

背景

番茄红素是一种具有强抗氧化活性的天然红色化合物，既可作为色素，又可作为功能性食品的原料，具有良好的商业前景。生物合成途径已被记录在案，这为使用生物技术生产番茄红素奠定了基础。

审查目的

虽然番茄红素生产已初具规模，但仍迫切需要缓解番茄红素的产量。该领域的进展可为利用多种途径进行番茄红素代谢工程生产提供有益参考。

综述的关键科学概念

使用传统的微生物发酵方法，生物技术人员通过选择合适的宿主菌株、使用各种添加剂和优化培养条件来提高番茄红素的产量。随着现代生物技术的发展，基因工程、蛋白质工程和代谢工程已被应用于生产番茄红素。从天然植物中提取是目前生产番茄红素的主要途径。基于番茄红素积累的分子机制，通过基因工程利用植物生物反应器生产番茄红素具有良好的前景。在这里，我们从生物技术的角度总结了优化番茄红素生产工程的常见策略，这些策略主要通过微生物培养来进行。我们回顾了这种方法的挑战和局限性，