It is a challenge to develop hemostatic and wound dressings that are used for irregular shape and deep wound. Herein, a series of novel N-succinyl chitosan-oxidized hyaluronic acid based (NSC-OHA-based) hydrogels were fabricated, while calcium ions (Ca²⁺) and/or four-armed amine-terminated poly(ethylene glycol) (4-arm-PEG-NH₂, labeled as PEG1) were introduced to regulate the mechanical behavior and bioactivities. We found all NSC-OHA-based hydrogels displayed self-healing and injectable performances. Besides, the addition of Ca²⁺ or PEG1 exhibited a positive effect on the adjustable mechanical behavior of hydrogels, providing the possibility to meet different mechanical requirements. Furthermore, Ca²⁺ or PEG1 significantly improved the biocompatibility, hemostasis and wound healing abilities of NSC-OHA hydrogel. Notably, compared with the commercial hemostatic agent (Arista™), hydrogels containing Ca²⁺ showed comparable hemostatic effects and significantly accelerated wound healing. Overall, the calcium-containing NSC-OHA hydrogels are promising for hemostasis and accelerating wound healing.

开发用于不规则形状和深层伤口的止血和伤口敷料是一项挑战。本文制备了一系列新型N-琥珀酰壳聚糖氧化透明质酸基 (NSC-OHA-based) 水凝胶，同时钙离子 (Ca ²⁺ ) 和/或四臂胺封端聚乙二醇 (4引入标记为PEG1的-arm-PEG-NH _{2 )来调节机械行为和生物活性。}我们发现所有基于 NSC-OHA 的水凝胶都显示出自愈和可注射性能。此外，Ca ²⁺或 PEG1 的添加对水凝胶的可调节力学行为表现出积极的影响，为满足不同的力学要求提供了可能性。此外，Ca ²⁺或 PEG1 显着提高了 NSC-OHA 水凝胶的生物相容性、止血和伤口愈合能力。值得注意的是，与市售止血剂 (Arista™) 相比，含有 Ca ²⁺的水凝胶表现出相当的止血效果并显着加速伤口愈合。总体而言，含钙的 NSC-OHA 水凝胶有望用于止血和加速伤口愈合。