DNA-modifying enzymes participate in various genetic functions (e.g., DNA replication, repairing, and recombination) through alternating certain DNA sequence, and the malfunction of DNA-modifying enzymes may disturb the normal genetic functions and consequently causes diverse human diseases. DNA-modifying enzymes may serve as the valuable diagnosis biomarkers and therapeutic targets, and the detection of DNA-modifying enzymes is essential to fundamental research, anticancer-drug discovery, and clinical diagnosis. Quantum dots (QDs) have many excellent electronic and optical characteristics, facilitating their biosensing and bioimaging applications. We review the development of QDs-based biosensors for DNA-modifying enzyme assays, and discuss current challenges and future directions in this field.

DNA修饰酶通过改变某些DNA序列参与多种遗传功能（如DNA复制、修复和重组），DNA修饰酶的功能失常可能会扰乱正常的遗传功能，从而导致多种人类疾病。DNA修饰酶可作为有价值的诊断生物标志物和治疗靶点，而DNA修饰酶的检测对于基础研究、抗癌药物发现和临床诊断至关重要。量子点 (QD) 具有许多优异的电子和光学特性，有助于其生物传感和生物成像应用。我们回顾了用于 DNA 修饰酶测定的基于量子点的生物传感器的发展，并讨论了该领域当前的挑战和未来的方向。