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Block Co-PolyMOC Micelles and Structural Synergy as Composite Nanocarriers
ACS Applied Materials & Interfaces ( IF 9.5 ) Pub Date : 2022-06-24 , DOI: 10.1021/acsami.2c06205
Lang Wang 1 , Zhongmin Geng 2, 3 , Yannis Y L Ho 1 , Jiayu Zhou 1 , Nicola Judge 1 , Yafei Li 4, 5 , Weiping Wang 4, 5 , Jinyao Liu 2 , Yufeng Wang 1
Affiliation  

Conventional micelles of amphiphilic block copolymers (BCPs) disassemble into individual polymer chains upon dilution to a critical concentration, which causes the premature release of the encapsulated drugs and reduces the drug’s bioavailability. Here, by integrating the emerging metal–organic cage (MOC) materials with BCPs, we introduce a new type of composite micellar nanoparticles, block co-polyMOC micelles (or BCPMMs), that are self-assembled in essence yet remarkably stable against dilution. BCPMMs are fabricated via a stepwise assembly strategy that combines MOCs and BCPs in a well-defined, unimolecular core–shell structure. The synergistical interplay between the two components accounts for the particle stability: the MOC core holds BCPs firmly in place and the BCPs increase the MOC’s bioavailability. When used as nanocarriers for anticancer drugs, BCPMMs showed an extended blood circulation, a favorable biodistribution, and eventually an improved treatment efficacy in vivo. Given the versatility in designing MOCs and BCPs, we envision that BCPMMs can serve as a modular platform for robust, multifunctional, and tunable nanomedicine.

中文翻译:

块状 Co-PolyMOC 胶束和结构协同作为复合纳米载体

两亲嵌段共聚物 (BCP) 的常规胶束在稀释至临界浓度后会分解成单独的聚合物链,这会导致封装药物过早释放并降低药物的生物利用度。在这里,通过将新兴的金属有机笼 (MOC) 材料与 BCP 相结合,我们引入了一种新型复合胶束纳米粒子,即嵌段共聚 MOC 胶束 (或 BCPMM),其本质上是自组装的,但对稀释非常稳定。BCPMM 是通过以下方式制造一种逐步组装策略,将 MOC 和 BCP 组合在明确的单分子核壳结构中。两种成分之间的协同作用解释了颗粒稳定性:MOC 核心将 BCP 牢牢固定在适当的位置,BCP 增加了 MOC 的生物利用度。当用作抗癌药物的纳米载体时,BCPMMs 表现出延长的血液循环、良好的生物分布,并最终提高了体内治疗效果。鉴于设计 MOC 和 BCP 的多功能性,我们设想 BCPMM 可以作为稳健、多功能和可调纳米医学的模块化平台。
更新日期:2022-06-24
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