Aggregation-induced emission (AIE)-active luminogens (AIEgens) have demonstrated exciting potential for the application in cancer phototheranostics. However, simultaneously achieving tumor-activated bright emission, enhanced reactive oxygen species (ROS) generation, high tumor accumulation, and minimized ROS depletion remains challenging. Here, a metal–organic framework (MOF) hybrid AIEgen theranostic platform is designed, termed A-NUiO@DCDA@ZIF-Cu, composed of an AIEgen-loaded hydrophobic UiO-66 (A-NUiO@DCDA) core and a Cu-doped hydrophilic ZIF-8 (ZIF-Cu) shell. The fluorescence emission and therapeutic ROS activity of AIEgens are restrained during delivery. After uptake by tumor tissues, ZIF-Cu decomposition occurs in response to an acidic tumor microenvironment (TME), and the hydrophobic A-NUiO@DCDA cores self-assemble into large particles, extremely increasing the tumor accumulation of AIEgens. This results in enhanced fluorescence imaging (FLI) and highly improved ¹O₂ generation ability during photodynamic therapy (PDT). Meanwhile, the released Cu²⁺ reacts to glutathione (GSH) to generate Cu⁺, which provides an extra chemodynamic therapy (CDT) function through Fenton-like reactions with overexpressed H₂O₂, resulting in the GSH depletion-enhanced ROS therapy. As a result of these characteristics, the MOF hybrid AIEgens can selectively kill tumors with excellent efficacy.

中文翻译：

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用于图像引导的 GSH 消耗 ROS 治疗的具有肿瘤激活积累和发射的工程金属-有机框架混合 AIEgens

聚集诱导发射 (AIE) 活性发光剂 (AIEgens) 在癌症光疗学中的应用已显示出令人兴奋的潜力。然而，同时实现肿瘤激活的明亮发射、增强的活性氧 (ROS) 生成、高肿瘤积累和最小化 ROS 消耗仍然具有挑战性。在这里，设计了一种金属-有机框架 (MOF) 混合 AIEgen 治疗平台，称为 A-NUiO@DCDA@ZIF-Cu，由负载 AIEgen 的疏水 UiO-66 (A-NUiO@DCDA) 核和 Cu-掺杂的亲水 ZIF-8 (ZIF-Cu) 壳。AIEgens 的荧光发射和治疗性 ROS 活性在递送过程中受到抑制。在被肿瘤组织吸收后，ZIF-Cu 在酸性肿瘤微环境 (TME) 下发生分解，疏水性 A-NUiO@DCDA 核自组装成大颗粒，极大地增加了 AIEgens 的肿瘤积累。这导致增强的荧光成像 (FLI) 和高度改进光动力疗法 (PDT) 期间产生¹ O _{2的能力。}同时，释放的 Cu ²⁺与谷胱甘肽 (GSH) 反应生成 Cu ^{+ ，通过与过表达的 H} ₂ O ₂的类芬顿反应提供额外的化学动力学治疗 (CDT) 功能，从而导致 GSH 消耗增强 ROS 治疗。由于这些特性，MOF杂合AIEgens可以选择性地杀死肿瘤，疗效极佳。