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Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-06-23 , DOI: 10.1039/d2lc00380e Alfredo Edoardo Ongaro 1 , Zibusiso Ndlovu 2 , Elodie Sollier 3 , Collins Otieno 4 , Pascale Ondoa 4 , Alice Street 5 , Maïwenn Kersaudy-Kerhoas 6, 7
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-06-23 , DOI: 10.1039/d2lc00380e Alfredo Edoardo Ongaro 1 , Zibusiso Ndlovu 2 , Elodie Sollier 3 , Collins Otieno 4 , Pascale Ondoa 4 , Alice Street 5 , Maïwenn Kersaudy-Kerhoas 6, 7
Affiliation
Single-use, disposable, point-of-care diagnostic devices carry great promise for global health, including meeting urgent needs for testing and diagnosis in places with limited laboratory facilities. Unfortunately, the production and disposal of single-use devices, whether in lateral flow assay, cartridges, cassettes, or lab-on-chip microfluidic format, also poses significant challenges for environmental and human health. Point-of-care devices are commonly manufactured from unsustainable polymeric materials derived from fossil sources. Their disposal often necessitates incineration to reduce infection risk, thereby creating additional release of CO2. Many devices also contain toxic chemicals, such as cyanide derivatives, that are damaging to environmental and human health if not disposed of safely. Yet, in the absence of government regulatory frameworks, safe and sustainable waste management for these novel medical devices is often left unaddressed. There is an urgent need to find novel solutions to avert environmental and human harm from these devices, especially in low- and middle-income countries where waste management infrastructure is often weak and where the use of point-of-care tests is projected to rise in coming years. We review here common materials used in the manufacture of single-use point-of-care diagnostic tests, examine the risks they pose to environmental and human health, and investigate replacement materials that can potentially reduce the impact of microfluidic devices on the production of harmful waste. We propose solutions available to point-of-care test developers to start embedding sustainability at an early stage in their design, and to reduce their non-renewable plastic consumption in research and product development.
中文翻译:
为现场诊断和一次性微流体设备设计可持续的未来
一次性、一次性、即时诊断设备为全球健康带来了巨大的希望,包括满足实验室设施有限的地方的测试和诊断的迫切需求。不幸的是,一次性设备的生产和处置,无论是侧流分析、卡盒、盒式磁带还是芯片实验室微流体形式,也给环境和人类健康带来了重大挑战。护理点设备通常由源自化石来源的不可持续聚合材料制成。它们的处置通常需要焚烧以降低感染风险,从而产生额外的 CO 2释放。许多设备还含有有毒化学物质,例如氰化物衍生物,如果不安全处置,会对环境和人类健康造成损害。然而,在缺乏政府监管框架的情况下,这些新型医疗设备的安全和可持续废物管理往往得不到解决。迫切需要找到新的解决方案来避免这些设备对环境和人类造成危害,特别是在废物管理基础设施往往薄弱且现场检测使用率预计会上升的低收入和中等收入国家未来几年。我们在此回顾了用于制造一次性护理点诊断测试的常用材料,检查它们对环境和人类健康构成的风险,并研究可潜在减少微流体设备对有害物质产生的影响的替代材料。浪费。我们为现场测试开发人员提供解决方案,以便在设计的早期阶段开始将可持续性融入其中,并减少研究和产品开发中的不可再生塑料消耗。
更新日期:2022-06-23
中文翻译:
为现场诊断和一次性微流体设备设计可持续的未来
一次性、一次性、即时诊断设备为全球健康带来了巨大的希望,包括满足实验室设施有限的地方的测试和诊断的迫切需求。不幸的是,一次性设备的生产和处置,无论是侧流分析、卡盒、盒式磁带还是芯片实验室微流体形式,也给环境和人类健康带来了重大挑战。护理点设备通常由源自化石来源的不可持续聚合材料制成。它们的处置通常需要焚烧以降低感染风险,从而产生额外的 CO 2释放。许多设备还含有有毒化学物质,例如氰化物衍生物,如果不安全处置,会对环境和人类健康造成损害。然而,在缺乏政府监管框架的情况下,这些新型医疗设备的安全和可持续废物管理往往得不到解决。迫切需要找到新的解决方案来避免这些设备对环境和人类造成危害,特别是在废物管理基础设施往往薄弱且现场检测使用率预计会上升的低收入和中等收入国家未来几年。我们在此回顾了用于制造一次性护理点诊断测试的常用材料,检查它们对环境和人类健康构成的风险,并研究可潜在减少微流体设备对有害物质产生的影响的替代材料。浪费。我们为现场测试开发人员提供解决方案,以便在设计的早期阶段开始将可持续性融入其中,并减少研究和产品开发中的不可再生塑料消耗。