The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representational formats for events from the same or different sequences. Structural knowledge about time patterns, abstracted from different sequences, biased the construction of specific event times. These findings demonstrate that mnemonic construction and the generalization of relational knowledge combine in the hippocampus, consistent with the simulation of scenarios from episodic details and structural knowledge.

海马-内嗅区支持对情节细节的记忆，例如连续事件的时间关系，以及结合经验进行推理的助记结构。然而，尚不清楚海马事件记忆是否反映了源自助记符结构、事件顺序或经过时间的时间关系，以及这些序列表示是否概括了相似序列之间的时间关系。在这里，参与者使用不常见的线索和他们消磨时间的经验，从多个序列中记忆构建事件的时间。学习后，前海马体中的事件表示反映了基于构建时间的时间关系。时间关系在序列中被概括，揭示来自相同或不同序列的事件的不同表示格式。从不同序列中抽象出来的关于时间模式的结构性知识偏向于特定事件时间的构建。这些发现表明，记忆结构和关系知识的泛化结合在海马体中，与情节细节和结构知识的场景模拟一致。