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Synthesis of Thioalkynes by Desilylative Sonogashira Cross-Coupling of Aryl Iodides and 1-Methylthio-2-(trimethylsilyl)ethyne
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2022-06-22 , DOI: 10.1002/ejoc.202200498
Yang Cao 1 , Yang Huang 1 , Paul R. Blakemore 1
Affiliation  

An efficient and operationally straightforward synthesis of 1-methylthio-2-arylethyne derivatives is described based on a desilylative Sonogashira cross-coupling between aryl iodides and a silylated surrogate for methylthioacetylene (Me3SiCCSMe). Extension of the process to a selection of other thioether types is also documented.

中文翻译:

芳基碘化物和 1-Methylthio-2-(trimethylsilyl)ethyne 的 Desilylative Sonogashira 交叉偶联合成硫代炔烃

基于芳基碘化物和甲硫基乙炔 (Me 3 SiCCSMe)的甲硅烷基化替代物之间的脱甲硅烷基 Sonogashira 交叉偶联,描述了一种高效且操作简单的 1-甲硫基-2-芳基乙炔衍生物合成方法。还记录了将该过程扩展到选择其他硫醚类型。
更新日期:2022-06-22
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