Palladium-catalyzed regioselective [5 + 1] annulation reactions of vinyl aziridines/epoxides with ClCF₂COONa have been developed. Significantly, vinyl aziridines/epoxides act as heteroatom-containing five-atom synthons, and commercially available and cheap ClCF₂COONa acts as the source of carbonyl serving as a difluorocarbene precursor. This protocol provides an efficient and practical method for the synthesis of δ-lactams and δ-lactones in good yields.

中文翻译：

---

钯催化的区域选择性 [5 + 1] 乙烯基氮丙啶/环氧化物与 ClCF2COONa 的环化

已经开发了钯催化的乙烯基氮丙啶/环氧化物与 ClCF ₂ COONa 的区域选择性 [5 + 1] 环化反应。重要的是，乙烯基氮丙啶/环氧化物充当含杂原子的五原子合成子，而市售且廉价的 ClCF ₂ COONa 充当用作二氟卡宾前体的羰基来源。该协议为以良好收率合成 δ-内酰胺和 δ-内酯提供了一种有效且实用的方法。