Tumor metastasis is a major cause of patient death. In order to improve the cure rate, tumor markers are necessary to investigate because they can reflect the progression and prognosis of tumor. The newly developed photoelectrochemical (PEC) sensors have become one of the most promising strategy in the field of tumor marker analysis in recent years due to their high sensitivity and low cost. More importantly, the combination of PEC technique with biosensing strategies is proved to be more advantageous than conventional sensing methods with higher specificity and sensitivity. Meanwhile, with the development of nanotechnology, novel PEC nanosensors will have greater potential for building more powerful signal amplification systems. This review focuses on the signal amplification strategies of PEC biosensors related to tumor marker detection in the last 5 years. Not only that, we also discussed the future prospects and challenges of PEC biosensor development.

肿瘤转移是患者死亡的主要原因。为了提高治愈率，有必要研究肿瘤标志物，因为它们可以反映肿瘤的进展和预后。新开发的光电化学（PEC）传感器由于其高灵敏度和低成本已成为近年来肿瘤标志物分析领域最有前途的策略之一。更重要的是，PEC技术与生物传感策略的结合被证明比传统的传感方法更具优势，具有更高的特异性和灵敏度。同时，随着纳米技术的发展，新型PEC纳米传感器在构建更强大的信号放大系统方面将具有更大的潜力。本综述重点介绍近5年来PEC生物传感器与肿瘤标志物检测相关的信号放大策略。不仅如此，我们还讨论了PEC生物传感器发展的未来前景和挑战。