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Constant light in early life induces fear-related behavior in chickens with suppressed melatonin secretion and disrupted hippocampal expression of clock- and BDNF-associated genes
Journal of Animal Science and Biotechnology ( IF 7 ) Pub Date : 2022-06-21 , DOI: 10.1186/s40104-022-00720-4
Yang Yang 1, 2 , Wei Cong 1, 2 , Jie Liu 1, 2 , Mindie Zhao 1, 2 , Peirong Xu 1, 2 , Wanwan Han 1, 2 , Deyun Wang 1, 3 , Ruqian Zhao 1, 2
Affiliation  

Light management plays an important role in the growth and behavior of broiler chickens. Constant light in early post hatch stage has been a common practice in broiler industry for improving growth performance, while whether and how constant light in early life affects the behavior of broiler chickens is rarely reported. In this study, newly hatched chicks were kept in either constant (24 L:0 D, LL) or (12 L:12 D, LD) photoperiod for 7 d and then maintained in 12 L:12 D thereafter until 21 days of age. Constant light increased the average daily feed intake but not the body weight, which led to higher feed conversion ratio. Chickens in LL group exhibited fear-related behaviors, which was associated with higher corticosterone, lower melatonin and 5-HT levels. Concurrently, constant light exposure increased the mRNA expression of clock-related genes and suppressed the expression of antioxidative genes in the hippocampus. Moreover, brain derived neurotrophic factor/extracellular signal-regulated kinase (BDNF/ERK) pathway was suppressed in the hippocampus of chickens exposed to constant light in the first week post hatching. These findings indicate that constant light exposure in early life suppress melatonin secretion and disrupts hippocampal expression of genes involved in circadian clock and BDNF/ERK pathway, thereby contributing to fear-related behaviors in the chicken.

中文翻译:

生命早期的持续光照会导致鸡的恐惧相关行为,褪黑激素分泌受到抑制,时钟和 BDNF 相关基因的海马表达被破坏

光照管理在肉鸡的生长和行为中起着重要作用。孵化后早期的恒定光照一直是肉鸡行业提高生长性能的常见做法,而早期的光照是否以及如何影响肉鸡的行为却鲜有报道。在这项研究中,新孵化的雏鸡在恒定的(24 L:0 D, LL)或(12 L:12 D, LD)光周期中保持 7 天,然后在 12 L:12 D 中保持至 21 日龄。 . 恒定光照增加了平均日采食量,但不增加体重,从而导致更高的饲料转化率。LL组鸡表现出与恐惧相关的行为,这与较高的皮质酮、较低的褪黑激素和5-HT水平有关。同时,持续的光照增加了时钟相关基因的 mRNA 表达并抑制了海马中抗氧化基因的表达。此外,在孵化后的第一周,暴露在恒定光照下的鸡的海马中,脑源性神经营养因子/细胞外信号调节激酶 (BDNF/ERK) 通路受到抑制。这些发现表明,生命早期持续的光照会抑制褪黑激素的分泌,并破坏与生物钟和 BDNF/ERK 通路相关的基因的海马表达,从而导致鸡的恐惧相关行为。在孵化后的第一周,暴露在恒定光照下的鸡的海马体中,脑源性神经营养因子/细胞外信号调节激酶 (BDNF/ERK) 通路受到抑制。这些发现表明,生命早期持续的光照会抑制褪黑激素的分泌,并破坏与生物钟和 BDNF/ERK 通路相关的基因的海马表达,从而导致鸡的恐惧相关行为。在孵化后的第一周,暴露在恒定光照下的鸡的海马体中,脑源性神经营养因子/细胞外信号调节激酶 (BDNF/ERK) 通路受到抑制。这些发现表明,生命早期持续的光照会抑制褪黑激素的分泌,并破坏与生物钟和 BDNF/ERK 通路相关的基因的海马表达,从而导致鸡的恐惧相关行为。
更新日期:2022-06-22
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