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Intra-articular versus systemic vancomycin for the treatment of periprosthetic joint infection after debridement and spacer implantation in a rat model.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2022-6-17 , DOI: 10.1302/2046-3758.116.bjr-2021-0319.r3
Jian Wei 1, 2 , Kai Tong 1, 2 , Hui Wang 3 , Yinxian Wen 1, 2 , Liaobin Chen 1, 2
Affiliation  

Treatment outcomes for methicillin-resistant Staphylococcus aureus (MRSA) periprosthetic joint infection (PJI) using systemic vancomycin and antibacterial cement spacers during two-stage revision arthroplasty remain unsatisfactory. This study explored the efficacy and safety of intra-articular vancomycin injections for PJI control after debridement and cement spacer implantation in a rat model.

中文翻译:

关节内与全身万古霉素治疗大鼠模型清创和间隔物植入后的假体周围感染。

在两阶段翻修关节成形术中使用全身万古霉素和抗菌水泥垫片治疗耐甲氧西林金黄色葡萄球菌(MRSA) 假体周围感染 (PJI) 的结果仍然不令人满意。本研究探讨了在大鼠模型中清创和水泥垫片植入后关节内注射万古霉素用于 PJI 控制的有效性和安全性。
更新日期:2022-06-17
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