With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public health. Accumulating evidence has shown that they have been linked to increased consumption of fructose in humans, we hereby made a timely review on the roles of fructose intake and the gut microbiota in regulating purine metabolism, together with the potential mechanisms by which excessive fructose intake contributes to hyperuricemia and gout. To this end, we focus on the understanding of the interaction between a fructose-rich diet and the gut microbiota in hyperuricemia and gout to seek for safe, cheap, and side-effect-free clinical interventions. Furthermore, fructose intake recommendations for hyperuricemia and gout patients, as well as the variety of probiotics and prebiotics with uric acid-lowering effects targeting the intestinal tract are also summarized to provide reference and guidance for the further research.

随着高尿酸血症及相关痛风的全球流行，嘌呤代谢紊乱疾病已成为对人类公共卫生的严重威胁。越来越多的证据表明，它们与人类果糖摄入量的增加有关，我们在此及时回顾了果糖摄入量和肠道菌群在调节嘌呤代谢中的作用，以及果糖摄入过多导致果糖摄入量增加的潜在机制。高尿酸血症和痛风。为此，我们专注于了解富含果糖的饮食与肠道菌群在高尿酸血症和痛风中的相互作用，以寻求安全、廉价和无副作用的临床干预措施。此外，对高尿酸血症和痛风患者的果糖摄入建议，