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The efficacy of low-intensity pulsed ultrasound on articular cartilage and clinical evaluations in patients with knee osteoarthritis
Journal of Back and Musculoskeletal Rehabilitation ( IF 1.6 ) Pub Date : 2022-06-16 , DOI: 10.3233/bmr-210357
Nam-Gyu Jo 1, 2 , Myoung-Hwan Ko 1, 2 , Yu Hui Won 1, 2 , Sung-Hee Park 1, 2 , Jeong-Hwan Seo 1, 2 , Gi-Wook Kim 1, 2
Affiliation  

BACKGROUND: While a number of preclinical studies have examined the effectiveness of low-intensity pulsed ultrasound (LIPUS) as a potential treatment for knee osteoarthritis (OA), there have been few clinical studies which have indirectly confirmed cartilage regeneration by magnetic resonance imaging (MRI). OBJECTIVE: The aim of this clinical trial was to investigate whether LIPUS effectively increased knee cartilage thickness and improved pain and function in knee OA patients. METHODS: This study was a prospective, single-group, home-based self-therapy trial. We included patients (n= 20) with OA pain. Each patient used an ultrasonic stimulation device (BODITREK JOINT™) for more than 20 sessions. Outcomes were assessed by MRI, Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the 36-Item Short Form Survey (SF-36) for assessing quality of life. RESULTS: Nineteen subjects completed this study. There was no significant increase in the cartilage thickness measured by MRI after LIPUS treatment. LIPUS therapy significantly decreased VAS score and WOMAC score, and significantly increased SF-36 score. The subgroup analysis in patients with knee OA showed that LIPUS treatment showed better for older patients with lower Kellgren-Lawrence grades. CONCLUSION: Pain, function, and quality of life improved after LIPUS, but there was no significant increase in cartilage thickness through MRI.

中文翻译:

低强度脉冲超声对膝骨关节炎患者关节软骨的疗效及临床评价

背景:虽然许多临床前研究已经检验了低强度脉冲超声 (LIPUS) 作为膝骨关节炎 (OA) 潜在治疗方法的有效性,但很少有临床研究通过磁共振成像 (MRI) 间接证实软骨再生). 目的:本临床试验的目的是研究 LIPUS 是否有效增加膝关节软骨厚度并改善膝关节 OA 患者的疼痛和功能。方法:本研究是一项前瞻性、单组、家庭自我治疗试验。我们纳入了患有 OA 疼痛的患者 (n = 20)。每位患者使用超声波刺激装置 (BODITREK JOINT™) 超过 20 次。结果通过 MRI、视觉模拟量表 (VAS)、西安大略和麦克马斯特大学骨关节炎指数 (WOMAC)、以及用于评估生活质量的 36 项简表调查 (SF-36)。结果:19 名受试者完成了这项研究。LIPUS 治疗后通过 MRI 测量的软骨厚度没有显着增加。LIPUS 治疗显着降低了 VAS 评分和 WOMAC 评分,并显着提高了 SF-36 评分。膝关节 OA 患者的亚组分析表明,LIPUS 治疗对 Kellgren-Lawrence 分级较低的老年患者效果更好。结论:LIPUS 后疼痛、功能和生活质量得到改善,但通过 MRI 显示软骨厚度没有显着增加。LIPUS 治疗显着降低了 VAS 评分和 WOMAC 评分,并显着提高了 SF-36 评分。膝关节 OA 患者的亚组分析表明,LIPUS 治疗对 Kellgren-Lawrence 分级较低的老年患者效果更好。结论:LIPUS 后疼痛、功能和生活质量得到改善,但通过 MRI 显示软骨厚度没有显着增加。LIPUS 治疗显着降低了 VAS 评分和 WOMAC 评分,并显着提高了 SF-36 评分。膝关节 OA 患者的亚组分析表明,LIPUS 治疗对 Kellgren-Lawrence 分级较低的老年患者效果更好。结论:LIPUS 后疼痛、功能和生活质量得到改善,但通过 MRI 显示软骨厚度没有显着增加。
更新日期:2022-06-16
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