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Emerging Biomaterials Imaging Antitumor Immune Response
Advanced Materials ( IF 29.4 ) Pub Date : 2022-06-21 , DOI: 10.1002/adma.202204034
Xianbin Ma 1, 2 , Meng-Jie Zhang 3 , Jingting Wang 1 , Tian Zhang 1 , Peng Xue 1 , Yuejun Kang 1 , Zhi-Jun Sun 3 , Zhigang Xu 1
Affiliation  

Immunotherapy is one of the most promising clinical modalities for the treatment of malignant tumors and has shown excellent therapeutic outcomes in clinical settings. However, it continues to face several challenges, including long treatment cycles, high costs, immune-related adverse events, and low response rates. Thus, it is critical to predict the response rate to immunotherapy by using imaging technology in the preoperative and intraoperative. Here, the latest advances in nanosystem-based biomaterials used for predicting responses to immunotherapy via the imaging of immune cells and signaling molecules in the immune microenvironment are comprehensively summarized. Several imaging methods, such as fluorescence imaging, magnetic resonance imaging, positron emission tomography imaging, ultrasound imaging, and photoacoustic imaging, used in immune predictive imaging, are discussed to show the potential of nanosystems for distinguishing immunotherapy responders from nonresponders. Nanosystem-based biomaterials aided by various imaging technologies are expected to enable the effective prediction and diagnosis in cases of tumors, inflammation, and other public diseases.

中文翻译:

新兴生物材料成像抗肿瘤免疫反应

免疫疗法是治疗恶性肿瘤的最有前途的临床方法之一,并在临床环境中显示出优异的治疗效果。然而,它仍然面临着几个挑战,包括治疗周期长、成本高、免疫相关的不良事件和低反应率。因此,在术前和术中使用成像技术预测免疫治疗的反应率至关重要。在这里,全面总结了基于纳米系统的生物材料的最新进展,用于通过免疫细胞和免疫微环境中的信号分子的成像来预测对免疫治疗的反应。几种成像方法,如荧光成像、磁共振成像、正电子发射断层扫描成像、超声成像和光声成像,讨论了用于免疫预测成像的纳米系统在区分免疫治疗反应者和无反应者方面的潜力。在各种成像技术的帮助下,基于纳米系统的生物材料有望在肿瘤、炎症和其他公共疾病的情况下进行有效的预测和诊断。
更新日期:2022-06-21
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