Given that biaryl motifs are found in many useful molecules, including pesticides, pharmaceuticals, functional materials, and polymers, the development of methods for their construction is important. Herein, we report a two-step method for C(sp²)–H/C(sp²)–H cross-coupling reactions to synthesize 2-arylindole derivatives by combining palladium catalysis and photocatalysis. This mild, dual-catalysis method showed good functional group tolerance and a wide substrate scope and could be used for late-stage functionalization of oligopeptides, drugs, and natural products.

中文翻译：

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钯金属光氧化还原催化吲哚衍生物的2-芳基化

鉴于联芳基基序存在于许多有用的分子中，包括杀虫剂、药物、功能材料和聚合物，因此开发它们的构建方法非常重要。在此，我们报道了一种通过钯催化和光催化相结合的 C(sp ² )-H/C(sp ² )-H 交叉偶联反应合成 2-芳基吲哚衍生物的两步法。这种温和的双催化方法表现出良好的官能团耐受性和广泛的底物范围，可用于寡肽、药物和天然产物的后期功能化。