Five Lycopodium alkaloids featuring novel C₁₇N₂ (1 and 2), C₂₉N₃ (3 and 4), and C₁₅N₂ (5) skeletons were isolated from Lycopodium japonicum. Compound 1 is the first natural product containing a 3-aza[3.3.3]propellane motif. The structures of these compounds were elucidated by spectroscopic analysis, X-ray crystallography, and computational methods. Compounds 1 and 3–5 significantly inhibited TGF-β₁-induced fibronectin deposition in HK-2 cells at a nontoxic concentration of 20 μM.

中文翻译：

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Lycojapomines A-E：来自石松的具有抗肾纤维化潜力的石松生物碱

从石松中分离出5种具有新型C ₁₇ N ₂ ( 1和2 )、C ₂₉ N ₃ ( 3和4 )和C ₁₅ N ₂ ( 5 )骨架的石松生物碱。化合物1是第一个含有 3-氮杂[3.3.3] 螺旋体基序的天然产物。通过光谱分析、X 射线晶体学和计算方法阐明了这些化合物的结构。化合物1和3-5显着抑制 TGF- _β1- 在 20 μM 的无毒浓度下诱导 HK-2 细胞中的纤连蛋白沉积。