Abstract

Nucleotides and platelets have been associated with a wide range of activities that affect the host inflammatory response. The main goal of this study is to examine the roles of nucleotide signaling and platelets in inflammation. The study analysis entailed conducting a systematic search to identify relevant articles in PsycINFO, PubMed, Web of Science, and CINAHL. The evidence gathered from the identified articles shows the roles of nucleotides and platelets in inflammation. In the extracellular environment, nucleotides act as signaling molecules that can activate nucleotide receptors to promote inflammation. Inflammation is an essential process through which the innate immune system responds to pathogens, microbes, and damage-associated molecular patterns. Moreover, research evidence shows that the mechanisms through which platelets affect inflammatory responses and regulate hemostasis are the same. The roles of nucleotides and platelets in inflammation have been explored in several studies worldwide. Although platelets and nucleotides have unique structures, both of them influence the host response to pathogens and tumors. Analysis of platelets and nucleotides will offer valuable insight for the development of new treatments for infectious and inflammatory diseases.

摘要

核苷酸和血小板与影响宿主炎症反应的广泛活动有关。本研究的主要目的是检查核苷酸信号传导和血小板在炎症中的作用。研究分析需要进行系统搜索，以确定 PsycINFO、PubMed、Web of Science 和 CINAHL 中的相关文章。从已确定的文章中收集的证据显示了核苷酸和血小板在炎症中的作用。在细胞外环境中，核苷酸充当信号分子，可以激活核苷酸受体以促进炎症。炎症是先天免疫系统对病原体、微生物和损伤相关分子模式作出反应的重要过程。而且，研究证据表明，血小板影响炎症反应和调节止血的机制是相同的。全世界的几项研究都探讨了核苷酸和血小板在炎症中的作用。尽管血小板和核苷酸具有独特的结构，但它们都会影响宿主对病原体和肿瘤的反应。血小板和核苷酸的分析将为开发感染性和炎症性疾病的新疗法提供有价值的见解。