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In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography
Journal of Pharmaceutical Analysis ( IF 8.8 ) Pub Date : 2022-06-20 , DOI: 10.1016/j.jpha.2022.06.005
Ning He 1, 2 , Zhentao Li 1, 2 , Changjun Hu 1 , Zilin Chen 1, 2
Affiliation  

Covalent organic frameworks (COFs) are a novel type of crystalline porous organic polymer materials recently developed. It has several advantages in chromatographic separation field, such as high thermal stability, porosity, structural regularity, and large specific surface area. Here, a novel spherical COF 1,3,5-tris(4-aminophenyl)benzene (TAPB) and 2,5-bis(2-propyn-1-yloxy)-1,4-benzenedicarboxaldehyde (BPTA) was developed as an electrochromatographic stationary phase for capillary electrochromatography separation. The COF TAPB-BPTA modified capillary column was fabricated via a facile in situ growth method at room temperature. The characterization results of scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and X-ray diffraction (XRD) confirmed that COF TAPB-BPTA were successfully modified onto the capillary inner surface. The electrochromatography separation performance of the COF TAPB-BPTA modified capillary was investigated. The prepared column demonstrated outstanding separation performance toward alkylbenzenes, phenols, and chlorobenzenes compounds. Furthermore, the baseline separations of non-steroidal anti-inflammatory drugs (NSAIDs) and parabens with good efficiency and high resolution were achieved. Also, the prepared column possessed satisfactory precision of the intra-day runs (n = 5), inter-day runs (n = 3), and parallel columns (n = 3), and the relative standard deviations (RSDs) of the retention times of tested alkylbenzenes were all less than 2.58%. Thus, this new COF-based stationary phase shows tremendous application potential in chromatographic separation field.



中文翻译:

原位合成球形共价有机骨架作为毛细管电色谱的固定相

共价有机骨架(COFs)是最近开发的一种新型结晶多孔有机聚合物材料。在色谱分离领域具有热稳定性高、孔隙率高、结构规整、比表面积大等优点。在这里,开发了一种新型球形 COF 1,3,5-三(4-氨基苯基)苯(TAPB)和 2,5-双(2-丙炔-1-基氧基)-1,4-苯二甲醛(BPTA)作为用于毛细管电色谱分离的电色谱固定相。COF TAPB-BPTA 改性毛细管柱是在室温下通过简便的原位生长方法制备的。扫描电子显微镜(SEM)、傅里叶变换红外(FT-IR)光谱的表征结果,和 X 射线衍射 (XRD) 证实 COF TAPB-BPTA 成功改性到毛细管内表面。考察了COF TAPB-BPTA改性毛细管的电色谱分离性能。制备的色谱柱对烷基苯、酚和氯苯化合物表现出出色的分离性能。此外,实现了非甾体抗炎药 (NSAID) 和对羟基苯甲酸酯的基线分离,具有良好的效率和高分辨率。此外,制备的色谱柱具有令人满意的日内运行精度(实现了高效和高分辨率的非甾体抗炎药 (NSAID) 和对羟基苯甲酸酯的基线分离。此外,制备的色谱柱具有令人满意的日内运行精度(实现了高效和高分辨率的非甾体抗炎药 (NSAID) 和对羟基苯甲酸酯的基线分离。此外,制备的色谱柱具有令人满意的日内运行精度(n  = 5)、日间运行 ( n  = 3) 和平行柱 ( n  = 3),被测烷基苯保留时间的相对标准偏差 (RSD) 均小于 2.58%。因此,这种基于 COF 的新型固定相在色谱分离领域显示出巨大的应用潜力。

更新日期:2022-06-20
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