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Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells
Hepatology ( IF 13.5 ) Pub Date : 2022-06-19 , DOI: 10.1002/hep.32622
Kaitao Zhao 1 , Fangteng Guo 1 , Jingjing Wang 1 , Youquan Zhong 1 , Junzhu Yi 1 , Yan Teng 1 , Zaichao Xu 1 , Li Zhao 1 , Aixin Li 1 , Zichen Wang 1 , Xinwen Chen 2, 3 , Xiaoming Cheng 1, 4, 5 , Yuchen Xia 1
Affiliation  

Murine hepatic cells cannot support hepatitis B virus (HBV) infection even with supplemental expression of viral receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). However, the specific restricted step remains elusive. In this study, we aimed to dissect HBV infection process in murine hepatic cells.

中文翻译:

细胞质乙型肝炎病毒核衣壳的有限分解限制了小鼠肝细胞的病毒感染

即使补充表达病毒受体、人牛磺胆酸钠协同转运多肽 (hNTCP),小鼠肝细胞也不能支持乙型肝炎病毒 (HBV) 感染。然而,具体的限制步骤仍然难以捉摸。在这项研究中,我们旨在剖析小鼠肝细胞中的 HBV 感染过程。
更新日期:2022-06-19
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