In a recent issue of Nature, Zuin et al. (2022) integrate a transcriptional enhancer into various genomic locations surrounding a reporter gene promoter in order to determine how enhancer-promoter proximity affects gene expression. Their findings suggest a non-linear relationship, which the authors explain via a quantitative biophysical model with intriguing biological implications.

中文翻译：

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短暂的相遇：增强子接近度与基因表达的关系

在最近一期的《自然》杂志上，Zuin 等人。(2022) 将转录增强子整合到报告基因启动子周围的各种基因组位置，以确定增强子-启动子接近度如何影响基因表达。他们的发现表明存在非线性关系，作者通过具有有趣生物学意义的定量生物物理模型对此进行了解释。