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Lipoprotein profiles associated with exposure to poly- and perfluoroalkyl substances (PFASs) in the EuroMix human biomonitoring study
Environmental Pollution ( IF 8.9 ) Pub Date : 2022-06-20 , DOI: 10.1016/j.envpol.2022.119664
Eleni Papadopoulou 1 , Alina Nicolescu 2 , Line S Haug 1 , Trine Husøy 1 , Calin Deleanu 2 , Hubert Dirven 1 , Birgitte Lindeman 1
Affiliation  

Exposure to per- and polyfluoroalkyl substances (PFASs) is associated with increased blood cholesterol. Although elevated cholesterol is a well-established risk factor for cardiovascular diseases (CVD), it is not clear whether PFASs affect this risk. Lipoprotein subclasses are emerging biomarkers for disease risk and lipoprotein profiling may provide an insight to physiological implications of PFAS exposure. We explored the association between serum PFAS concentrations and lipoprotein subclasses in a cross-sectional study. We determined the concentrations and lipid composition of the major subclasses of lipoproteins in plasma samples from 127 adult participants of the EuroMix human biomonitoring study by nuclear magnetic resonance (NMR). Serum concentrations of 17 PFASs showed a detection frequency between 30 and 100% and were included in further analyses. We examined the associations between PFAS concentrations and lipoprotein subclasses by linear mixed-effect regression models, adjusted for confounders. In the adjusted models, positive associations were found between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. We found a 4–12% increase in HDL cholesterol per interquartile range (IQR) increase for several PFASs. In women the associations with PFNA, PFUnDA, PFDoDA and PFOS were significant after adjustment for multiple comparisons. Similar magnitude of change was observed between longer chained PFASs and LDL cholesterol, and a few of these associations reached significance for cholesterol in large to medium LDL particle sizes in women. No significant associations with plasma triglycerides were observed. However, most PFASs tended to be associated with reduction in VLDL (very low-density lipoproteins) particle number and VLDL triglyceride. Findings from this exploratory study, suggest that background PFAS exposures influence particle size distributions and lipid composition of plasma lipoprotein subclasses, and that these effects may be more prominent in women. A two-points lipoprofiling for all subjects indicated both low intra-individual variability and good analytical reproducibility.



中文翻译:

EuroMix 人体生物监测研究中与暴露于多氟烷基物质和全氟烷基物质 (PFAS) 相关的脂蛋白谱

暴露于全氟和多氟烷基物质 (PFAS) 与血液胆固醇升高有关。尽管胆固醇升高是心血管疾病 (CVD) 的公认危险因素,但尚不清楚 PFAS 是否会影响这种风险。脂蛋白亚类是疾病风险的新兴生物标志物,脂蛋白分析可以提供对 PFAS 暴露的生理影响的洞察。我们在一项横断面研究中探讨了血清 PFAS 浓度与脂蛋白亚类之间的关联。我们通过核磁共振 (NMR) 确定了 EuroMix 人体生物监测研究的 127 名成年参与者血浆样本中主要脂蛋白亚类的浓度和脂质组成。17 种 PFAS 的血清浓度显示检测频率在 30% 和 100% 之间,并被纳入进一步分析。我们通过线性混合效应回归模型检查了 PFAS 浓度和脂蛋白亚类之间的关联,并针对混杂因素进行了调整。在调整后的模型中,发现几种 PFAS 与大中型 HDL 和中型 LDL 颗粒中的胆固醇浓度呈正相关。我们发现几种 PFAS 的每四分位间距 (IQR) 增加 4-12% 的 HDL 胆固醇增加。在女性中,经过多重比较调整后,与 PFNA、PFUnDA、PFDoDA 和 PFOS 的关联显着。在长链 PFAS 和 LDL 胆固醇之间观察到类似程度的变化,并且其中一些关联对女性中大到中等 LDL 颗粒大小的胆固醇具有重要意义。未观察到与血浆甘油三酯的显着相关性。然而,大多数 PFAS 往往与 VLDL(极低密度脂蛋白)颗粒数量和 VLDL 甘油三酯的减少有关。这项探索性研究的结果表明,背景 PFAS 暴露会影响血浆脂蛋白亚类的粒径分布和脂质组成,并且这些影响在女性中可能更为突出。所有受试者的两点脂肪分析表明个体内变异性低和分析重现性好。大多数 PFAS 往往与 VLDL(极低密度脂蛋白)颗粒数量和 VLDL 甘油三酯的减少有关。这项探索性研究的结果表明,背景 PFAS 暴露会影响血浆脂蛋白亚类的粒径分布和脂质组成,并且这些影响在女性中可能更为突出。所有受试者的两点脂肪分析表明个体内变异性低和分析重现性好。大多数 PFAS 往往与 VLDL(极低密度脂蛋白)颗粒数量和 VLDL 甘油三酯的减少有关。这项探索性研究的结果表明,背景 PFAS 暴露会影响血浆脂蛋白亚类的粒径分布和脂质组成,并且这些影响在女性中可能更为突出。所有受试者的两点脂肪分析表明个体内变异性低和分析重现性好。

更新日期:2022-06-20
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