In 2012, arterolane (ART) in combination with piperaquine received approval in India for the treatment of plasmodium-induced malaria; however, to date, a detailed metabolite identification study of ART has not been reported. Being polar in nature, ART shows early elution on reversed-phase columns which might be the rate-limiting factor of its systematic analytical studies. We have utilized hydrophilic interaction liquid chromatography (HILIC) to separate in vitro and in vivo metabolites of ART.

中文翻译：

---

使用亲水相互作用液相色谱-四极杆飞行时间质谱法对阿特罗兰代谢物进行综合鉴定研究

2012年，arterolane（ART）联合哌喹在印度获得批准用于治疗疟原虫引起的疟疾；然而，迄今为止，尚未报道 ART 的详细代谢物鉴定研究。ART 本质上是极性的，在反相色谱柱上表现出早期洗脱，这可能是其系统分析研究的限速因素。我们利用亲水相互作用液相色谱 (HILIC) 分离体外和体内ART 的代谢物。