In this work, the supercritical CO₂-assisted impregnation of microcrystalline cellulose (MCC) particles with R-(−)-carvone, an antimicrobial monoterpene, was investigated. The effect of CO₂ density (278–600 kg m⁻³), temperature (40–60 °C), carvone:MCC mass ratio (0.5–1.0), and depressurization mode (cold–hot), on the impregnation yield was studied. Carvone loadings were obtained in the range of 0.6–3.6 wt%, and the addition of ethanol (2 wt%) as cosolvent enhanced the impregnation yield up to 10 wt%. The high crystallinity of cellulose (81–84%) remained unchanged after the supercritical process, although SEM analysis showed a partial separation of fiber agglomerates. Carvone release in simulated saliva solution from particles impregnated using cosolvent was slightly slower than from the pure CO₂-impregnated particles. The observed release profile could be useful for pharmaceutical and biomedical applications, such as the prevention of oral cavity infections or their treatment at early stages.

在这项工作中，研究了超临界 CO ₂辅助浸渍具有抗菌单萜的R -(-)-香芹酮的微晶纤维素 (MCC) 颗粒。CO ₂密度的影响（278–600 kg m ^-3）、温度（40-60°C）、香芹酮：MCC质量比（0.5-1.0）和减压模式（冷-热）对浸渍产率的影响进行了研究。香芹酮负载量在 0.6-3.6 wt% 范围内，添加乙醇（2 wt%）作为助溶剂将浸渍产率提高到 10 wt%。超临界过程后纤维素的高结晶度（81-84%）保持不变，尽管 SEM 分析显示纤维团块部分分离。使用助溶剂浸渍的颗粒在模拟唾液溶液中的香芹酮释放比纯CO ₂浸渍的颗粒稍慢。观察到的释放曲线可用于药物和生物医学应用，例如预防口腔感染或早期治疗。