Acetaminophen (ACMP) was synthesized in mixed-solvents (H₂O-acetone, H₂O-dimethyl sulfoxide, H₂O-isopropyl alcohol) for purposes of eliminating hazardous dipolar aprotic solvents. The H₂O-acetone solvent-pair gave synthesized ACMP yields of 79.2%. Synthesized ACMP samples were encapsulated using solution enhanced dispersion by supercritical CO₂ (SEDS) at 150 bar, 45 °C, 1.5 mL/min feed flow rate (30 mg ACMP/mL in mixed-solvent), CO₂ flow rate of 15 L/min (1 bar, 25 °C) in which suitable products could not be formed with PEG-4000 excipient at ACMP:PEG ratios of 1:1 with mixed-solvents, however, with ethyl cellulose (EC) excipient at ACMP:EC ratios of 1:1 and ethanol-acetone mixed-solvent (x:y, v/v, x = 1–9, y = 9–1), encapsulated products could be formed over the full range of mixed-solvent compositions. ACMP encapsulated fine particles had purities as high as 99.9% demonstrating that SEDS with safe mixed-solvents can broaden methods available for encapsulating pharmaceuticals.

为了消除危险的偶极非质子溶剂，在混合溶剂（H ₂ O-丙酮、H ₂ O-二甲基亚砜、H ₂ O-异丙醇）中合成了对乙酰氨基酚 (ACMP)。H ₂ O-丙酮溶剂对的合成ACMP产率为79.2%。_{合成的 ACMP 样品使用超临界 CO 2} (SEDS) 在 150 bar、45 °C、1.5 mL/min 进料流速（在混合溶剂中为 30 mg ACMP/mL）、CO ₂下的溶液增强分散进行封装在 15 L/min (1 bar, 25 °C) 的流速下，使用 PEG-4000 赋形剂在 ACMP:PEG 比例为 1:1 的混合溶剂中无法形成合适的产品，但是使用乙基纤维素 (EC) ACMP:EC 比例为 1:1 和乙醇-丙酮混合溶剂 ( x : y , v/v, x  = 1-9, y  = 9-1) 的赋形剂，可以在整个混合范围内形成封装产品-溶剂组合物。ACMP 包封细颗粒的纯度高达 99.9%，这表明带有安全混合溶剂的 SEDS 可以拓宽可用于包封药物的方法。