Plastic products are widely used in different applications. Thus, exposure of human and other organisms to these products may affect their biological system. The current study was conducted to investigate the potential deleterious effect of Polysterene nanoparticles (PS-NPs) on the liver and to state the cellular and molecular mechanisms associated with exposure to PS-NPs.30 male rats were divided randomly and equally into 3 groups; control (distilled water), low dose (3 mg/kg/day) and high dose (10 mg/kg/day) exposed group via oral gavage for 5 successive weeks. PS-NPs caused elevation in ALT, AST and MDA, upregulation of apoptosis-related genes and significant decrease in GSH and mRNA expression for antioxidant-related genes (Nrf-2 and GPx). Moreover, alterations in hepatic tissue architecture and positive caspase-3 expression was noticed in a dose- dependent manner. Collectively, PS-NPs can induce hepatoxicity in rats in a dose dependent manner, so the health risk of PS-NPs should not be ignored.

塑料制品广泛用于不同的应用。因此，人类和其他生物体接触这些产品可能会影响它们的生物系统。目前的研究旨在调查聚苯乙烯纳米颗粒 (PS-NPs) 对肝脏的潜在有害影响，并阐明与接触 PS-NPs 相关的细胞和分子机制。将 30 只雄性大鼠随机平均分为 3 组；对照组（蒸馏水）、低剂量（3 mg/kg/天）和高剂量（10 mg/kg/天）暴露组，连续5周经口灌胃。PS-NPs 导致 ALT、AST 和 MDA 升高，细胞凋亡相关基因上调，抗氧化相关基因（Nrf-2 和 GPx）的 GSH 和 mRNA 表达显着降低。而且，肝组织结构的改变和 caspase-3 阳性表达以剂量依赖性方式被观察到。总的来说，PS-NPs 可以以剂量依赖性方式诱导大鼠肝毒性，因此 PS-NPs 的健康风险不容忽视。