Recently, increasing studies have suggested that miRNAs play a significant role in the occurrence and development of glioma. More researches are needed to explore the role of miRNAs in glioma, which will help to find new therapeutic targets. miR-212-5p has been reported to be involved in the progression in many cancers. However, whether miR-212-5p has a regulative effect on glioma remains un clear. In this study, we aimed to explore the effect of miR-212-5p on glioma development and its mechanism. Here, we demonstrated that miR-212-5p was lowly expressed in glioma cell. miR-212-5p suppressed the glioma cell proliferation, inhibited the migratory and invasive capabilities and promoted apoptosis in glioma cells. Besides, miR-212-5p also inhibited tumor growth in vivo. We found small ubiquitin-like modifier 2 (SUMO2) was the target of miR-212-5p, and miR-212-5p suppressed SUMO2 expression to regulate the proliferation, migration, and apoptosis of glioma cells. These findings indicated that miR-212-5p may be a possible therapeutic target for the treatment for glioma.

近年来，越来越多的研究表明，miRNAs在胶质瘤的发生发展过程中发挥着重要作用。需要更多的研究来探索miRNA在胶质瘤中的作用，这将有助于寻找新的治疗靶点。据报道，miR-212-5p 参与许多癌症的进展。然而，miR-212-5p是否对胶质瘤有调节作用尚不清楚。本研究旨在探讨miR-212-5p对胶质瘤发生发展的影响及其机制。在这里，我们证明了 miR-212-5p 在神经胶质瘤细胞中低表达。miR-212-5p 抑制胶质瘤细胞增殖，抑制迁移和侵袭能力，促进胶质瘤细胞凋亡。此外，miR-212-5p还在体内抑制肿瘤生长。我们发现小泛素样修饰物 2 (SUMO2) 是 miR-212-5p 的靶标，miR-212-5p通过抑制SUMO2的表达来调节胶质瘤细胞的增殖、迁移和凋亡。这些发现表明 miR-212-5p 可能是治疗神经胶质瘤的可能治疗靶点。