To develop dental restorative materials with enamel-like structures, ultralong hydroxyapatite (HA) nanowires were synthesized by a hydrothermal method, followed by functionalization with 3-methacryloxypropyltrimethoxysilane (KH-570). The mixture of HA nanowires, KH-570, and light initiator was stirred and centrifuged. The precipitate was vacuum filtered to remove excessive KH-570 and then pressured under cold isostatic pressing (10 MPa × 24 h). Finally, the block was polymerized by lighting. Scanning electron microscopy and transmission electron microscopy showed that HA nanowires with aspect ratios >1,000 were assembled into enamel rod–like microstructures and evenly dispersed in the polymerized KH-570 silane matrix to form enamel-like structures. Thermogravimetric analysis demonstrated that the content of HA nanowires reached 72 wt% in the composite. The enamel-like composite showed a similar hardness, frictional property, and acid-etching property to those of enamel and a comparable or even better diametral tensile strength and compressive strength than some commercial composite resins in mechanical tests in vitro. In addition, the enamel-like composite had good cytocompatibility. Such enamel-like composites may have the potential to be used in biomimetic tooth restorations in the future.

为了开发具有牙釉质结构的牙齿修复材料，通过水热法合成超长羟基磷灰石 (HA) 纳米线，然后用 3-甲基丙烯酰氧基丙基三甲氧基硅烷 (KH-570) 进行功能化。将 HA 纳米线、KH-570 和光引发剂的混合物搅拌并离心。将沉淀物真空过滤以除去过量的 KH-570，然后在冷等静压 (10 MPa × 24 h) 下加压。最后，通过光照使块聚合。扫描电子显微镜和透射电子显微镜显示，长宽比 > 1,000 的 HA 纳米线组装成搪瓷棒状微结构，并均匀分散在聚合的 KH-570 硅烷基体中，形成搪瓷状结构。热重分析表明，HA纳米线在复合材料中的含量达到了72 wt%。在体外机械试验中，该类搪瓷复合材料表现出与搪瓷相似的硬度、摩擦性能和酸蚀性能，以及与一些商业复合树脂相当甚至更好的径向拉伸强度和抗压强度。此外，牙釉质状复合物具有良好的细胞相容性。这种类似牙釉质的复合材料在未来可能具有用于仿生牙齿修复的潜力。该牙釉质状复合物具有良好的细胞相容性。这种类似牙釉质的复合材料在未来可能具有用于仿生牙齿修复的潜力。该牙釉质状复合物具有良好的细胞相容性。这种类似牙釉质的复合材料在未来可能具有用于仿生牙齿修复的潜力。