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A WNT protein therapeutic accelerates consolidation of a bone graft substitute in a pre-clinical sinus augmentation model
Journal of Clinical Periodontology ( IF 6.7 ) Pub Date : 2022-06-17 , DOI: 10.1111/jcpe.13674
Benjamin R Coyac 1, 2 , Benjamin J Wolf 1 , Daniel J Bahat 1 , Masaki Arioka 1 , John B Brunski 1 , Jill A Helms 1
Affiliation  

Autologous bone grafts consolidate faster than bone graft substitutes (BGSs) but resorb over time, which compromises implant support. We hypothesized that differences in consolidation rates affected the mechanical properties of grafts and implant stability, and tested whether a pro-osteogenic protein, liposomal WNT3A (L-WNT3A), could accelerate graft consolidation.

中文翻译:

WNT 蛋白治疗剂在临床前鼻窦增大模型中加速骨移植替代物的巩固

自体骨移植物比骨移植物替代物 (BGS) 更快地巩固,但随着时间的推移会吸收,这会损害种植体的支持。我们假设巩固率的差异会影响移植物的机械性能和植入物的稳定性,并测试了促成骨蛋白脂质体 WNT3A (L-WNT3A) 是否可以加速移植物的巩固。
更新日期:2022-06-17
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