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Diversity-Oriented Synthesis and Chemoinformatics: A Fruitful Synergy towards Better Chemical Libraries
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2022-06-17 , DOI: 10.1002/ejoc.202200575
Elena Lenci 1 , Andrea Trabocchi 2
Affiliation  

In these two decades, Diversity Oriented Syntesis (DOS) has evolved significantly. A shift in the focus of DOS library design was observed, passing from structural diversity to biological relevance. New approaches have been developed taking advantage of chemoinformatics tools, in order to increase the biological outcome of the library.

中文翻译:

面向多样性的合成和化学信息学:对更好的化学图书馆的卓有成效的协同作用

在这两个十年中,面向多样性的综合 (DOS) 发生了显着变化。观察到 DOS 文库设计的重点发生了转变,从结构多样性转移到了生物学相关性。利用化学信息学工具开发了新的方法,以增加文库的生物学结果。
更新日期:2022-06-17
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