The construction of porous nanocarriers with good lubricating performance and stimuli-responsive drug release is significant for the synergetic therapy of osteoarthritis (OA). Although metal-organic framework nanoparticles (nanoMOFs) as carriers can support drug delivery, achieving the synergy of aqueous lubrication and stimuli-responsive drug release is challenging. In this work, a core-shell nanoMOFs@poly(N-isopropylacrylamide) (PNIPAm) microgel hybrid via one-pot soap-free emulsion polymerization is developed. Programmable growth of the PNIPAm microgel layer on the surface of nanoMOFs is achieved by tuning the concentration of the monomer and the crosslinker in the reaction. Reversible swelling-collapsing behaviors of the hybrid are realized by tuning the temperature below and above the lower critical solution temperature. When used as water lubrication additives, the hybrid enables reductions in both the coefficient of friction and wear volume. In vitro thermal-responsive drug release is demonstrated on the diclofenac sodium-loaded hybrid by controlling the swelling and collapsing states of the PNIPAm nanolayer. Moreover, the good biocompatibility of the hybrid is verified by culturing toward HeLa and BEAS-2B cells. These results establish a nanoMOFs@microgel hybrid that can achieve friction and wear reduction and thermal-responsive drug release.

中文翻译：

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用于水润滑和热响应药物释放的核壳纳米MOFs@microgel的构建

构建具有良好润滑性能和刺激响应药物释放的多孔纳米载体对于骨关节炎（OA）的协同治疗具有重要意义。尽管作为载体的金属有机骨架纳米颗粒（nanoMOFs）可以支持药物递送，但实现水润滑和刺激响应药物释放的协同作用具有挑战性。在这项工作中，通过一锅无皂乳液聚合开发了核壳纳米MOFs@聚（N-异丙基丙烯酰胺）（PNIPAm）微凝胶杂化物。通过调节反应中单体和交联剂的浓度，实现了 PNIPAm 微凝胶层在 nanoMOF 表面上的可编程生长。通过调节低于和高于较低临界溶解温度的温度来实现杂化物的可逆膨胀-坍塌行为。当用作水润滑添加剂时，该混合物可以降低摩擦系数和磨损量。通过控制 PNIPAm 纳米层的膨胀和塌陷状态，在负载双氯芬酸钠的杂化物上展示了体外热响应药物释放。此外，通过向HeLa和BEAS-2B细胞培养验证了该杂交体良好的生物相容性。这些结果建立了一种纳米MOFs@微凝胶混合物，可以实现减少摩擦和磨损以及热响应药物释放。通过对 HeLa 和 BEAS-2B 细胞的培养验证了杂交体良好的生物相容性。这些结果建立了一种纳米MOFs@微凝胶混合物，可以实现减少摩擦和磨损以及热响应药物释放。通过对 HeLa 和 BEAS-2B 细胞的培养验证了杂交体良好的生物相容性。这些结果建立了一种纳米MOFs@微凝胶混合物，可以实现减少摩擦和磨损以及热响应药物释放。