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Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Nature Reviews Cancer ( IF 78.5 ) Pub Date : 2022-06-16 , DOI: 10.1038/s41568-022-00486-x
Ryan C Gimple 1 , Kailin Yang 2 , Matthew E Halbert 3 , Sameer Agnihotri 3 , Jeremy N Rich 4, 5
Affiliation  

Malignant brain tumours are complex ecosystems containing neoplastic and stromal components that generate adaptive and evolutionarily driven aberrant tissues in the central nervous system. Brain cancers are cultivated by a dynamic population of stem-like cells that enforce intratumoural heterogeneity and respond to intrinsic microenvironment or therapeutically guided insults through proliferation, plasticity and restructuring of neoplastic and stromal components. Far from a rigid hierarchy, heterogeneous neoplastic populations transition between cellular states with differential self-renewal capacities, endowing them with powerful resilience. Here we review the biological machinery used by brain tumour stem cells to commandeer tissues in the intracranial space, evade immune responses and resist chemoradiotherapy. Through recent advances in single-cell sequencing, improved models to investigate the role of the tumour microenvironment and a deeper understanding of the fundamental role of the immune system in cancer biology, we are now better equipped to explore mechanisms by which these processes can be exploited for therapeutic benefit.



中文翻译:

脑癌干细胞:通过适应性可塑性和层次异质性恢复

恶性脑肿瘤是复杂的生态系统,包含肿瘤和基质成分,在中枢神经系统中产生适应性和进化驱动的异常组织。脑癌由动态的干细胞群培养,这些干细胞通过肿瘤和基质成分的增殖、可塑性和重组来增强肿瘤内异质性并对内在微环境或治疗引导的损伤作出反应。远离严格的等级制度,异质性肿瘤种群在具有不同自我更新能力的细胞状态之间转变,赋予它们强大的复原力。在这里,我们回顾了脑肿瘤干细胞用于征用颅内空间组织、逃避免疫反应和抵抗放化疗的生物机制。

更新日期:2022-06-17
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