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Free Radical Promoted Trifluoromethylthiolation of Alkynes to Access SCF3-Containing Dibenzazepines or Dioxodibenzothiazepines
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2022-06-16 , DOI: 10.1021/acs.joc.2c00623
Yingming Ren 1 , Qinqin Yan 1 , Yang Li 1 , Yongjun Gao 1 , Jincan Zhao 1 , Lijun Li 1 , Zhong-Quan Liu 2 , Zejiang Li 1
Affiliation  

Persulfate-promoted radical cascade trifluoromethylthiolation of aryl acetylenes with AgSCF3 provides a simple reaction system for the synthesis of SCF3-substituted dibenzazepines or dioxodibenzothiazepines with good Z/E selectivity. The single-crystal X-ray diffraction data confirms the structures of the final products. A series of scaled-up experiments, further transformations, and radical inhibition experiments were operated in the reaction system.

中文翻译:

自由基促进炔烃的三氟甲基硫醇化以获得含 SCF3 的二苯并氮杂或二氧代二苯并硫氮杂

过硫酸盐促进芳基乙炔与 AgSCF 3的自由基级联三氟甲基硫醇化反应为合成具有良好Z / E选择性的 SCF 3取代的二苯并二氮杂或二氧代二苯并硫氮杂提供了一个简单的反应体系。单晶 X 射线衍射数据证实了最终产品的结构。在反应体系中进行了一系列放大实验、进一步转化和自由基抑制实验。
更新日期:2022-06-16
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