A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective S_N2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral S^VI derivatives such as sulfoximines and sulfonimidamides is demonstrated.

中文翻译：

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对映体纯环状亚磺酰胺的合成方法

_{基于完全非对映选择性 S N} 2' 环化/叔丁基裂解序列，开发了一种合成方法，用于合成具有多达四个连续立体中心的对映纯环状亚磺酰胺。证明了将获得的支架非对映特异性转化为手性 S ^VI衍生物，例如亚砜​​亚胺和磺胺类药物。