In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a “partially extruded state” and that CTCF-CTCF loops are rare.

中文翻译：

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TAD 不会留在循环中

在最近一期的《科学》杂志上，Gabriele 等人。首次通过结合超分辨率成像和计算建模来量化活细胞中拓扑关联域 (TAD) 的动力学，得出的结论是，TAD 大部分时间都处于“部分挤压状态”，而 CTCF -CTCF 循环很少见。