The fluidity of the liposomes is essential to nanoparticle–membrane interactions. We herein report a liposomal nanomotor system by controlling the self-assembly behavior of gold core–platinum shell nanoparticles (Au@Pt) on liposomes. Au@Pt can aggregate immediately on fluid-phase dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes, forming an uneven distribution. By control of the lipid phase and fluidity, either using pure 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) above its phase transition temperature or adding cholesterol as an adjuvant to DPPC lipids, we precisely control the assembly of Au@Pt on liposomes. Au@Pt maintained high catalase-like activity on the liposomal surface, promoting the decomposition of H₂O₂ and the movement of the liposomal nanomotors. Finally, we demonstrate that liposomal nanomotors are biocompatible and they can speed up the cellular uptake in mammalian HepG2 cancer cells and Nicotiana tabacum (Nb) plant leaves. This liposomal nanomotor system is expected to be further investigated in biomedicine and plant nanotechnology.

中文翻译：

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Au@Pt 在脂质体上的流体引导组装作为过氧化氢酶驱动的纳米马达，用于癌细胞和植物叶片中的有效细胞摄取

脂质体的流动性对于纳米颗粒-膜相互作用至关重要。我们在此通过控制金核-铂壳纳米粒子 (Au@Pt) 在脂质体上的自组装行为来报告脂质体纳米马达系统。Au@Pt 可以立即聚集在液相二油酰基-sn-甘油-3-磷酸胆碱 (DOPC) 脂质体上，形成不均匀分布。通过控制脂质相和流动性，使用高于其相变温度的纯 1,2-二棕榈酰-sn-甘油-3-磷酸胆碱 (DPPC) 或添加胆固醇作为 DPPC 脂质的佐剂，我们精确控制了 Au 的组装@Pt 在脂质体上。Au@Pt 在脂质体表面保持高的类过氧化氢酶活性，促进 H ₂ O _2的分解和脂质体纳米马达的运动。最后，我们证明脂质体纳米马达具有生物相容性，它们可以加速哺乳动物 HepG2 癌细胞和烟草( Nb ) 植物叶片的细胞摄取。这种脂质体纳米马达系统有望在生物医学和植物纳米技术中得到进一步研究。