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An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma
CA: A Cancer Journal for Clinicians ( IF 254.7 ) Pub Date : 2022-06-16 , DOI: 10.3322/caac.21729
Elshad Hasanov 1 , Debra Nana Yeboa 2 , Mathew D Tucker 3 , Todd A Swanson 2 , Thomas Hendrix Beckham 2 , Brian Rini 3 , Chibawanye I Ene 4 , Merve Hasanov 1 , Sophie Derks 5 , Marion Smits 5 , Shaan Dudani 6 , Daniel Y C Heng 7 , Priscilla K Brastianos 8 , Axel Bex 9, 10, 11 , Sahin Hanalioglu 12 , Jeffrey S Weinberg 4 , Laure Hirsch 13, 14 , Maria I Carlo 15 , Ayal Aizer 16 , Paul David Brown 17 , Mehmet Asim Bilen 18, 19 , Eric Lin Chang 20 , Jerry Jaboin 21 , James Brugarolas 22, 23 , Toni K Choueiri 14 , Michael B Atkins 24 , Bradley A McGregor 14 , Lia M Halasz 25 , Toral R Patel 22, 26 , Scott G Soltys 27 , David F McDermott 28 , James Bradley Elder 29 , Mustafa K Baskaya 30 , James B Yu 31 , Robert Timmerman 22, 32 , Michelle Miran Kim 33 , Melike Mut 12 , James Markert 34 , Kathryn Beal 35 , Nizar M Tannir 36 , George Samandouras 37, 38 , Frederick F Lang 4 , Rachel Giles 39 , Eric Jonasch 36
Affiliation  

Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:454-489.

中文翻译:

肾细胞癌患者脑转移治疗的跨学科共识

脑转移是肾细胞癌的一个具有挑战性的表现。我们对脑转移瘤和免疫生物学、对全身治疗耐药的驱动因素及其总体预后不良的了解有限。目前的数据支持放射治疗和/或手术的多模式治疗策略。尽管如此,治疗肾细胞癌脑转移的最佳方法仍不清楚。为了改善患者护理,作者寻求标准化实际管理策略。他们通过来自不同学科的国际专家小组通过国际肾癌联盟的网络进行了非结构化的文献回顾并详细阐述了当前的管理策略。来自不同学科的专家接受了一项调查,以回答与当前挑战和未满足的患者需求相关的问题。在文献回顾和调查研究结果的综合方法的基础上,作者建立了肾细胞癌患者单发和多发脑转移的管理算法。本报告中介绍的文献回顾、共识声明和算法可以作为指导患者治疗决策的框架。CA 癌症 J 临床。2022;72:454-489。
更新日期:2022-06-16
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