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Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta
Nature Structural & Molecular Biology ( IF 16.8 ) Pub Date : 2022-06-16 , DOI: 10.1038/s41594-022-00788-6
Justin D Walter 1 , Sille Remm 1 , Markus A Seeger 1
Affiliation  

MFSD2A mediates uptake of the essential fatty acid DHA across the blood–brain barrier. Separately, via interactions with syncytin-2, MFSD2A contributes to the formation of the mother–fetus placental boundary. Cryo-EM analysis of a human MFSD2A–syncytin-2 complex provides new insights into how MFSD2A performs these dual roles.

中文翻译:

脂肪酸转运蛋白 MFSD2A 是大脑和胎盘中的多功能看门人

MFSD2A 介导必需脂肪酸 DHA 穿过血脑屏障的摄取。另外,通过与 syncytin-2 的相互作用,MFSD2A 有助于母胎胎盘边界的形成。人类 MFSD2A-syncytin-2 复合物的冷冻电镜分析为 MFSD2A 如何发挥这些双重作用提供了新的见解。
更新日期:2022-06-16
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