Coexisting of anti-Ro52 autoantibodies on anti-MDA5 autoantibodies-positive dermatomyositis is highly associated with rapidly progressive interstitial lung disease and mortality risk.,The Journal of Rheumatology

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Coexisting of anti-Ro52 autoantibodies on anti-MDA5 autoantibodies-positive dermatomyositis is highly associated with rapidly progressive interstitial lung disease and mortality risk.
The Journal of Rheumatology ( IF 3.9 ) Pub Date : 2022-06-15 , DOI: 10.3899/jrheum.220139
Chengyin Lv ₁ , Hanxiao You ₁ , Lingxiao Xu ₁ , Lei Wang ₁ , Fenghong Yuan ₂ , Ju Li ₃ , Min Wu ₄ , Shiliang Zhou ₄ , Zhanyun Da ₅ , Jie Qian ₅ , Hua Wei ₆ , Wei Yan ₆ , Lei Zhou ₇ , Yan Wang ₇ , Songlou Yin ₈ , Dongmei Zhou ₈ , Jian Wu ₉ , Yan Lu ₁₀ , Dinglei Su ₁₁ , Zhichun Liu ₁₂ , Lin Liu ₁₃ , Longxin Ma ₁₄ , Xiaoyan Xu ₁₅ , Yinshan Zang ₁₆ , Huijie Liu ₁₇ , Tianli Ren ₁₈ , Fang Wang ₁₉ , Miaojia Zhang ₂₀ , Wenfeng Tan ₂₀

Affiliation

C. Lv, MD, H. You, MD, PhD, L. Xu, MD, PhD, L. Wang, MD, PhD, M. Zhang, MD, W. Tan, MD, PhD, Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing.
F. Yuan, MD, Department of Rheumatology and Immunology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi.
J. Li, MD, Department of Rheumatology, Huai'an First People's Hospital, Huai'an, Jiangsu.
M. Wu, MD, S. Zhou, MD, Department of Rheumatology, The First People's Hospital of Changzhou, Changzhou.
Z. Da, MD, J. Qian, MD, Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong.
H. Wei, MD, W. Yan, MD, Department of Rheumatology, Northern Jiangsu People's Hospital, Yangzhou.
L. Zhou, MD, Y. Wang, MD, Department of Rheumatology, Changzhou No.2 People's Hospital, Changzhou.
S. Yin, MD, D. Zhou, MD, Department of Rheumatology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou.
J. Wu, MD, Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou.
Y. Lu, MD, Department of Rheumatology, Jiangsu Province Hospital of Chinese Medicine, Nanjing.
D. Su, MD, Department of Rheumatology, Nanjing First Hospital, Nanjing.
Z. Liu, MD, Department of Rheumatology, The Second Affiliated Hospital of Soochow University, Suzhou.
L. Liu, MD, Department of Rheumatology, Xuzhou Central Hospital, Xuzhou.
L. Ma, MD, Department of Rheumatology, Yancheng No.1 People's Hospital, Yancheng.
X. Xu, MD, Department of Rheumatology, Zhongda Hospital Southeast University, Nanjing.
Y. Zang, MD, Department of Rheumatology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian.
H. Liu, MD, Department of Rheumatology, The First People's Hospital of Lianyungang, Lianyungang.
T. Ren, MD, Department of Rheumatology, Wuxi No.2 People's Hospital, Wuxi.
F. Wang, MD, PhD, Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, China, Nanjing, Jiangsu, China.
C. Lv, MD, H. You, MD, PhD, L. Xu, MD, PhD, L. Wang, MD, PhD, M. Zhang, MD, W. Tan, MD, PhD, Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing;

Interstitial lung disease (ILD) is a common extramuscular complication contributing to significant morbidity and mortality in anti-melanoma differentiation associated gene 5 positive dermatomyositis (anti-MDA5+ DM). We conducted this study to investigate the association of anti-Ro52 antibodies with clinical characteristics and prognosis in anti-MDA5+ DM patients.

中文翻译：

抗 Ro52 自身抗体与抗 MDA5 自身抗体阳性皮肌炎共存与快速进展性间质性肺病和死亡风险高度相关。

间质性肺病 (ILD) 是一种常见的肌肉外并发症，可导致抗黑色素瘤分化相关基因 5 阳性皮肌炎（抗 MDA5+ DM）的显着发病率和死亡率。我们进行了这项研究，以调查抗 Ro52 抗体与抗 MDA5+ DM 患者的临床特征和预后的关联。

更新日期：2022-06-15

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