Abstract

Cocaine abuse has attracted increased attention in the recent past since it can cause addiction and great harm to the normal human body. Due to cocaine exists in various complex matrices, the detection of it in different matrices is helpful to prevent abuse. It is thus imperative to establish efficient and accurate methods for pretreatment and detection of cocaine in different samples. The present study provides a summary of the research progress of cocaine pretreatment methods (such as different microextraction methods, QuEChERS, and solid phase extraction based on novel extraction materials) and detection approaches (such as liquid chromatography coupled with different detectors, gas chromatography and related techniques, capillary electrophoresis and sensors). A comparison of the pros and cons of different pretreatment and detection methods is presented. The findings of this study will provide a reference for selection of the most suitable cocaine pretreatment and detection techniques.

摘要

可卡因滥用近年来引起了越来越多的关注，因为它会导致成瘾和对正常人体的巨大伤害。由于可卡因存在于各种复杂的基质中，在不同的基质中检测可卡因有助于防止滥用。因此，必须建立有效和准确的方法来预处理和检测不同样品中的可卡因。本研究总结了可卡因预处理方法（如不同的微萃取方法、QuEChERS、基于新型萃取材料的固相萃取）和检测方法（如液相色谱结合不同检测器、气相色谱等）的研究进展。技术、毛细管电泳和传感器）。比较了不同预处理和检测方法的优缺点。本研究结果将为选择最合适的可卡因预处理和检测技术提供参考。