Procollagen type I C-terminal propeptide (PICP) and procollagen type III N-terminal propeptide (PIIINP) are markers reflecting collagen synthesis in cardiac fibrosis. However, they may be influenced by the presence of non-cardiac comorbidities (e.g. ageing, obesity, renal impairment). Understanding the associations between markers of collagen synthesis and abnormalities of cardiac structure and function is important to screen for myocardial fibrosis and monitor the antifibrotic effect of medications.

中文翻译：

---

有心力衰竭风险的患者 I 型胶原合成标志物与对螺内酯的超声心动图反应之间的关联：来自 HOMAGE 试验的结果

I 型前胶原 C 端前肽 (PICP) 和 III 型前胶原 N 端前肽 (PIIINP) 是反映心脏纤维化中胶原合成的标志物。然而，它们可能会受到非心脏合并症（如衰老、肥胖、肾功能损害）的影响。了解胶原合成标志物与心脏结构和功能异常之间的关联对于筛查心肌纤维化和监测药物的抗纤维化作用非常重要。