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Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure.
Science ( IF 56.9 ) Pub Date : 2022-07-15 , DOI: 10.1126/science.abq1841 Catherine J Reynolds 1 , Corinna Pade 2 , Joseph M Gibbons 2 , Ashley D Otter 3 , Kai-Min Lin 1 , Diana Muñoz Sandoval 1 , Franziska P Pieper 1 , David K Butler 1 , Siyi Liu 1 , George Joy 4 , Nasim Forooghi 4 , Thomas A Treibel 4, 5 , Charlotte Manisty 4, 5 , James C Moon 4, 5 , , , Amanda Semper 3 , Tim Brooks 3 , Áine McKnight 2 , Daniel M Altmann 6 , Rosemary J Boyton 1, 7 , Hakam Abbass , Aderonke Abiodun , Mashael Alfarih , Zoe Alldis , Daniel M Altmann , Oliver E Amin , Mervyn Andiapen , Jessica Artico , João B Augusto , Georgina L Baca , Sasha N L Bailey , Anish N Bhuva , Alex Boulter , Ruth Bowles , Rosemary J Boyton , Olivia V Bracken , Ben O'Brien , Tim Brooks , Natalie Bullock , David K Butler , Gabriella Captur , Olivia Carr , Nicola Champion , Carmen Chan , Aneesh Chandran , Tom Coleman , Jorge Couto de Sousa , Xose Couto-Parada , Eleanor Cross , Teresa Cutino-Moguel , Silvia D'Arcangelo , Rhodri H Davies , Brooke Douglas , Cecilia Di Genova , Keenan Dieobi-Anene , Mariana O Diniz , Anaya Ellis , Karen Feehan , Malcolm Finlay , Marianna Fontana , Nasim Forooghi , Sasha Francis , Joseph M Gibbons , David Gillespie , Derek Gilroy , Matt Hamblin , Gabrielle Harker , Georgia Hemingway , Jacqueline Hewson , Wendy Heywood , Lauren M Hickling , Bethany Hicks , Aroon D Hingorani , Lee Howes , Ivie Itua , Victor Jardim , Wing-Yiu Jason Lee , Melaniepetra Jensen , Jessica Jones , Meleri Jones , George Joy , Vikas Kapil , Caoimhe Kelly , Hibba Kurdi , Jonathan Lambourne , Kai-Min Lin , Siyi Liu , Aaron Lloyd , Sarah Louth , Mala K Maini , Vineela Mandadapu , Charlotte Manisty , Áine McKnight , Katia Menacho , Celina Mfuko , Kevin Mills , Sebastian Millward , Oliver Mitchelmore , Christopher Moon , James Moon , Diana Muñoz Sandoval , Sam M Murray , Mahdad Noursadeghi , Ashley Otter , Corinna Pade , Susana Palma , Ruth Parker , Kush Patel , Mihaela Pawarova , Steffen E Petersen , Brian Piniera , Franziska P Pieper , Lisa Rannigan , Alicja Rapala , Catherine J Reynolds , Amy Richards , Matthew Robathan , Joshua Rosenheim , Cathy Rowe , Matthew Royds , Jane Sackville West , Genine Sambile , Nathalie M Schmidt , Hannah Selman , Amanda Semper , Andreas Seraphim , Mihaela Simion , Angelique Smit , Michelle Sugimoto , Leo Swadling , Stephen Taylor , Nigel Temperton , Stephen Thomas , George D Thornton , Thomas A Treibel , Art Tucker , Ann Varghese , Jessry Veerapen , Mohit Vijayakumar , Tim Warner , Sophie Welch , Hannah White , Theresa Wodehouse , Lucinda Wynne , Dan Zahedi , Benjamin Chain , James C Moon
Science ( IF 56.9 ) Pub Date : 2022-07-15 , DOI: 10.1126/science.abq1841 Catherine J Reynolds 1 , Corinna Pade 2 , Joseph M Gibbons 2 , Ashley D Otter 3 , Kai-Min Lin 1 , Diana Muñoz Sandoval 1 , Franziska P Pieper 1 , David K Butler 1 , Siyi Liu 1 , George Joy 4 , Nasim Forooghi 4 , Thomas A Treibel 4, 5 , Charlotte Manisty 4, 5 , James C Moon 4, 5 , , , Amanda Semper 3 , Tim Brooks 3 , Áine McKnight 2 , Daniel M Altmann 6 , Rosemary J Boyton 1, 7 , Hakam Abbass , Aderonke Abiodun , Mashael Alfarih , Zoe Alldis , Daniel M Altmann , Oliver E Amin , Mervyn Andiapen , Jessica Artico , João B Augusto , Georgina L Baca , Sasha N L Bailey , Anish N Bhuva , Alex Boulter , Ruth Bowles , Rosemary J Boyton , Olivia V Bracken , Ben O'Brien , Tim Brooks , Natalie Bullock , David K Butler , Gabriella Captur , Olivia Carr , Nicola Champion , Carmen Chan , Aneesh Chandran , Tom Coleman , Jorge Couto de Sousa , Xose Couto-Parada , Eleanor Cross , Teresa Cutino-Moguel , Silvia D'Arcangelo , Rhodri H Davies , Brooke Douglas , Cecilia Di Genova , Keenan Dieobi-Anene , Mariana O Diniz , Anaya Ellis , Karen Feehan , Malcolm Finlay , Marianna Fontana , Nasim Forooghi , Sasha Francis , Joseph M Gibbons , David Gillespie , Derek Gilroy , Matt Hamblin , Gabrielle Harker , Georgia Hemingway , Jacqueline Hewson , Wendy Heywood , Lauren M Hickling , Bethany Hicks , Aroon D Hingorani , Lee Howes , Ivie Itua , Victor Jardim , Wing-Yiu Jason Lee , Melaniepetra Jensen , Jessica Jones , Meleri Jones , George Joy , Vikas Kapil , Caoimhe Kelly , Hibba Kurdi , Jonathan Lambourne , Kai-Min Lin , Siyi Liu , Aaron Lloyd , Sarah Louth , Mala K Maini , Vineela Mandadapu , Charlotte Manisty , Áine McKnight , Katia Menacho , Celina Mfuko , Kevin Mills , Sebastian Millward , Oliver Mitchelmore , Christopher Moon , James Moon , Diana Muñoz Sandoval , Sam M Murray , Mahdad Noursadeghi , Ashley Otter , Corinna Pade , Susana Palma , Ruth Parker , Kush Patel , Mihaela Pawarova , Steffen E Petersen , Brian Piniera , Franziska P Pieper , Lisa Rannigan , Alicja Rapala , Catherine J Reynolds , Amy Richards , Matthew Robathan , Joshua Rosenheim , Cathy Rowe , Matthew Royds , Jane Sackville West , Genine Sambile , Nathalie M Schmidt , Hannah Selman , Amanda Semper , Andreas Seraphim , Mihaela Simion , Angelique Smit , Michelle Sugimoto , Leo Swadling , Stephen Taylor , Nigel Temperton , Stephen Thomas , George D Thornton , Thomas A Treibel , Art Tucker , Ann Varghese , Jessry Veerapen , Mohit Vijayakumar , Tim Warner , Sophie Welch , Hannah White , Theresa Wodehouse , Lucinda Wynne , Dan Zahedi , Benjamin Chain , James C Moon
Affiliation
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
中文翻译：
B.1.1.529 (Omicron) 的免疫增强作用取决于之前的 SARS-CoV-2 暴露情况。
Omicron 或 Pango 谱系 B.1.1.529 是严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的变种，携带多个尖峰突变，具有高传播性和部分中和抗体 (nAb) 逃逸。接种疫苗的个体可以预防严重疾病，这通常归因于已启动的细胞免疫。我们调查了具有不同 SARS-CoV-2 感染史、接种了三重 BioNTech BNT162b2 信使 RNA 疫苗的医护人员 (HCW) 中针对 B.1.1.529 的 T 细胞和 B 细胞免疫。在三重疫苗接种的个体中，针对先前关注的变体的 B 和 T 细胞免疫增强，但针对 B.1.1.529 刺突蛋白的 T 和 B 细胞反应程度降低。早期 B.1.1.7 (Alpha) 变体感染产生的免疫印记导致针对 B.1.1.529 的结合抗体的持久性较差。在 B.1.1.529 波期间感染的先前未感染过的医护人员表现出针对早期变体的免疫力增强，但针对 B.1.1.529 本身的 nAb 效力和 T 细胞反应降低。之前的武汉 Hu-1 感染消除了 T 细胞识别和 B.1.1.529 感染时增强的交叉反应中和免疫力。
更新日期：2022-06-14
中文翻译：
B.1.1.529 (Omicron) 的免疫增强作用取决于之前的 SARS-CoV-2 暴露情况。
Omicron 或 Pango 谱系 B.1.1.529 是严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的变种，携带多个尖峰突变，具有高传播性和部分中和抗体 (nAb) 逃逸。接种疫苗的个体可以预防严重疾病，这通常归因于已启动的细胞免疫。我们调查了具有不同 SARS-CoV-2 感染史、接种了三重 BioNTech BNT162b2 信使 RNA 疫苗的医护人员 (HCW) 中针对 B.1.1.529 的 T 细胞和 B 细胞免疫。在三重疫苗接种的个体中，针对先前关注的变体的 B 和 T 细胞免疫增强，但针对 B.1.1.529 刺突蛋白的 T 和 B 细胞反应程度降低。早期 B.1.1.7 (Alpha) 变体感染产生的免疫印记导致针对 B.1.1.529 的结合抗体的持久性较差。在 B.1.1.529 波期间感染的先前未感染过的医护人员表现出针对早期变体的免疫力增强，但针对 B.1.1.529 本身的 nAb 效力和 T 细胞反应降低。之前的武汉 Hu-1 感染消除了 T 细胞识别和 B.1.1.529 感染时增强的交叉反应中和免疫力。
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