(+)- and (−)-Chlorahupetenes A (1a and 1b), B (2a and 2b), C (3a and 3b), and D (4a and 4b), four unique enantiomeric pairs of eudesmane-type sesquiterpenoid dimers with two new carbon skeletons, were isolated from the aerial parts of Chloranthus henryi var. hupehensis. Compounds 1 and 2 possess an unprecedented 6/6/5/6/6 pentacyclic carbon skeleton with a new dimerization pattern of two eudesmane-type sesquiterpenoids. Compounds 3 and 4, which are fused with two eudesmane-type sesquiterpenoids via an unprecedented five-membered O-heterocyclic ring, represent a new 6/6/5/5/6/6/5 heptacyclic ring system. The structures of the compounds were determined through spectroscopic data and X-ray crystallography. Compounds 1a–3b significantly inhibited NO production with IC₅₀ values ranging from 9.62 to 12.91 μM. Moreover, compounds 1b and 3a suppressed the production of a proinflammatory mediator (TNF-α) and enzyme expression (iNOS) at the mRNA level.

中文翻译：

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Chlorahupetenes A-D，四种 Eudesmane 型倍半萜二聚体对映体，具有来自 Chloranthus henryi Var 的两个不寻常的碳骨架。湖北人

(+)- 和 (-)-Chlorahupetenes A ( 1a和1b )、B ( 2a和2b )、C ( 3a和3b ) 和 D ( 4a和4b )，四个独特的对映异构体对 eudesmane 型倍半萜二聚体从Chloranthus henryi var的地上部分分离出两个新的碳骨架。湖北_ 化合物1和2具有前所未有的 6/6/5/6/6 五环碳骨架，具有两种 eudesmane 型倍半萜的新二聚模式。化合物3和4，它们通过前所未有的五元O-杂环与两个eudesmane型倍半萜类稠合，代表了一种新的6/6/5/5/6/6/5七环系统。通过光谱数据和 X 射线晶体学确定化合物的结构。化合物1a – 3b显着抑制 NO 的产生，IC ₅₀值范围为 9.62 至 12.91 μM。此外，化合物1b和3a在 mRNA 水平上抑制促炎介质 (TNF-α) 和酶表达 (iNOS) 的产生。