Gut microbiota modulation might constitute a mechanism mediating the effects of beer on health. In this randomized, double-blinded, two-arm parallel trial, 22 healthy men were recruited to drink 330 mL of nonalcoholic beer (0.0% v/v) or alcoholic beer (5.2% v/v) daily during a 4-week follow-up period. Blood and faecal samples were collected before and after the intervention period. Gut microbiota was analyzed by 16S rRNA gene sequencing. Drinking nonalcoholic or alcoholic beer daily for 4 weeks did not increase body weight and body fat mass and did not changed significantly serum cardiometabolic biomarkers. Nonalcoholic and alcoholic beer increased gut microbiota diversity which has been associated with positive health outcomes and tended to increase faecal alkaline phosphatase activity, a marker of intestinal barrier function. These results suggest the effects of beer on gut microbiota modulation are independent of alcohol and may be mediated by beer polyphenols.

中文翻译：

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饮用啤酒和不含酒精的啤酒对肠道微生物群的影响：一项随机、双盲、对照试验

肠道微生物群调节可能构成调节啤酒对健康影响的机制。在这项随机、双盲、两臂平行试验中，招募了 22 名健康男性，在为期 4 周的随访期间每天饮用 330 mL 不含酒精的啤酒 (0.0% v/v) 或含酒精的啤酒 (5.2% v/v)期。在干预期前后收集血液和粪便样本。通过 16S rRNA 基因测序分析肠道微生物群。连续 4 周每天饮用不含酒精或酒精的啤酒并没有增加体重和体脂肪量，也没有显着改变血清心脏代谢生物标志物。不含酒精和酒精的啤酒增加了肠道微生物群的多样性，这与积极的健康结果有关，并且往往会增加粪便碱性磷酸酶活性，这是肠道屏障功能的标志。