Distinct dendritic cell (DC) subsets exert specific functions in immune regulation, but their communication with each other has remained elusive. In this issue of Immunity, Gargaro et al. identify the IDO1-Kyn-AHR axis as a metabolic signaling pathway through which conventional DC subsets communicate and induce tolerogenicity.

中文翻译：

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cDC1 到 cDC2：“我所做的一切，我都为你做”

不同的树突状细胞 (DC) 亚群在免疫调节中发挥特定功能，但它们之间的交流仍然难以捉摸。在本期Immunity中，Gargaro 等人。将 IDO1-Kyn-AHR 轴鉴定为代谢信号通路，常规 DC 亚群通过该通路进行通信并诱导耐受性。