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Robust variation in infant gut microbiome assembly across a spectrum of lifestyles
Science ( IF 56.9 ) Pub Date : 2022-06-09 , DOI: 10.1126/science.abj2972
Matthew R Olm 1 , Dylan Dahan 1 , Matthew M Carter 1 , Bryan D Merrill 1 , Feiqiao B Yu 2 , Sunit Jain 2 , Xiandong Meng 3 , Surya Tripathi 4 , Hannah Wastyk 1 , Norma Neff 2 , Susan Holmes 1, 5 , Erica D Sonnenburg 1 , Aashish R Jha 6 , Justin L Sonnenburg 1, 2
Affiliation  

Infant microbiome assembly has been intensely studied in infants from industrialized nations, but little is known about this process in nonindustrialized populations. We deeply sequenced infant stool samples from the Hadza hunter-gatherers of Tanzania and analyzed them in a global meta-analysis. Infant microbiomes develop along lifestyle-associated trajectories, with more than 20% of genomes detected in the Hadza infant gut representing novel species. Industrialized infants—even those who are breastfed—have microbiomes characterized by a paucity of Bifidobacterium infantis and gene cassettes involved in human milk utilization. Strains within lifestyle-associated taxonomic groups are shared between mother-infant dyads, consistent with early life inheritance of lifestyle-shaped microbiomes. The population-specific differences in infant microbiome composition and function underscore the importance of studying microbiomes from people outside of wealthy, industrialized nations.

中文翻译:

不同生活方式下婴儿肠道微生物组的显着变化

已经对来自工业化国家的婴儿进行了深入的婴儿微生物组组装研究,但对非工业化人群中的这一过程知之甚少。我们对来自坦桑尼亚哈扎狩猎采集者的婴儿粪便样本进行了深度测序,并在全球荟萃分析中对其进行了分析。婴儿微生物组沿着与生活方式相关的轨迹发展,在 Hadza 婴儿肠道中检测到的超过 20% 的基因组代表新物种。工业化婴儿——即使是母乳喂养的婴儿——微生物组的特点是缺乏婴儿双歧杆菌和涉及母乳利用的基因盒。与生活方式相关的分类群中的菌株在母婴二元体之间共享,这与生活方式微生物组的早期生命遗传一致。婴儿微生物组组成和功能的人群特异性差异强调了研究富裕工业化国家以外人群的微生物组的重要性。
更新日期:2022-06-09
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