Funding Acknowledgements Type of funding sources: None. Aim To study frequency and nature of psychopathological symptoms in various forms of somatogenic asthenic syndrome in patients with high cardiovascular risk (CVR). Methods The quantitative anamnestic analysis of medical history, the variational statistics, the probabilistic allocation of clinical signs with estimation of reliability of the results. Among the 199 persons with high CVR and non-psychotic mental disorders: 31 patients had somatogenic asthenic syndrome (SAS), stratified by clinical variants: asthenic (1n2=14); asthenic-anxious (2n2=8); asthenic-subdepressive (3n2=6) and dyssomniac (4n2=3). Results The frequency and kind of pathopsychological symptoms in young people with increased CVR and SAS was studied. Each variant of SAS in patients with high CVR has its features of symptomological structure. More, than in half of cases in asthenic variant of SAS in patients with high CVR, registered a headache, a feeling of heaviness in the head (63.4±12.8%), intolerance to loud sounds and bright lights (57.1±13.2%) and low mood (50.0±13.4%). Patients with high CVR and asthenic-anxious variant of SAS on the first place by the frequency of diagnosing was also weakness (87.5±11.7%), lack of vigor after a night's sleep (87.5±11.7%) and almost with the same frequency were registered fatigue (75.0±15.3%), memory impairment (62.5±17.1%), which in 1.5-3 times exceeded the average in patients with SAS by the frequency; anxiety, absentmindedness were diagnosed in 50.0±17.7% of cases in this subgroup. Prevailing (most common) psychopathological symptoms, significantly more represented than on the average in patients with high CVR and dyssomniac variant of SAS were (at 65-100%): absentmindedness, irritability, fatigue, weakness, anxiety. Most common symptom in patients with high CVR and asthenic variant of SAS was a weakness - in (92.9±6.9)%, and the prevalence was significantly higher, than on the average in group of patients with SAS. There were fatigue (85.7±9.4%), tearfulness (85.7±9.4%), irritability (63.4±12.8%), difficulty falling asleep (57.1±13.2%), the prevalence of which significantly exceeded the average in patients with SAS (p<0.05). In patients with high CVR and asthenic-anxious SAS on the first place by the frequency of diagnosis was also weakness (87.5±11.7%), lack of vigor after a night's sleep (87.5±11.7%) almost on the same frequency was registered fatigue (75.0±15.3%), memory impairment (62.5±17.1%), which in 1.5-3 times exceeded the average in patients with SAS by the frequency. Most common for patients with high CVR and asthenic-subdepressive variant of SAS were: dizziness (83.3±15.2), sleep disorders and restless sleep (66.7±19.2%), touchiness and anguish (66.7±19.2%). Conclusions Ranking of symptoms was made and the major syndromes, depending on the variant of SAS in patients with high CVR, were defined.

中文翻译：

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心血管高危患者的体源性虚弱综合征的各个方面

资金确认 资金来源类型：无。目的研究高心血管风险（CVR）患者各种形式的体源性虚弱综合征的精神病理学症状的频率和性质。方法对病史进行定量记忆分析、变分统计、临床体征的概率分配以及结果的可靠性估计。在 199 名高 CVR 和非精神病性精神障碍患者中：31 名患者患有体源性虚弱综合征（SAS），按临床变异分层：虚弱（1n2=14）；虚弱焦虑（2n2=8）；虚弱-亚抑郁（3n2=6）和失眠症（4n2=3）。结果研究了CVR和SAS增加的年轻人的病理心理症状的频率和种类。高 CVR 患者 SAS 的每个变体都有其症状结构特征。在高 CVR 患者中，超过一半的 SAS 虚弱变异型患者出现头痛、头部沉重感（63.4±12.8%）、不耐响亮的声音和强光（57.1±13.2%）和情绪低落（50.0±13.4%）。高 CVR 和 SAS 虚弱焦虑变异型的患者按诊断频率排在首位的也有虚弱（87.5±11.7%）、一夜睡眠后缺乏活力（87.5±11.7%）和几乎相同的频率。出现疲劳（75.0±15.3%）、记忆力减退（62.5±17.1%），超过 SAS 患者平均值的 1.5-3 倍；该亚组中有 50.0±17.7% 的病例被诊断为焦虑、心不在焉。普遍的（最常见的）精神病理学症状，在具有高 CVR 和 SAS 失眠变体的患者中，显着高于平均水平（65-100%）：心不在焉、易怒、疲劳、虚弱、焦虑。高 CVR 和 SAS 虚弱变异型患者最常见的症状是虚弱 - （92.9±6.9）％，患病率显着高于 SAS 患者组的平均水平。SAS患者出现乏力（85.7±9.4%）、流泪（85.7±9.4%）、易怒（63.4±12.8%）、入睡困难（57.1±13.2%），其患病率明显超过平均水平（p<< ;0.05)。在高 CVR 和虚弱焦虑 SAS 患者中，按诊断频率排在首位的也是虚弱（87.5±11.7%），夜间睡眠后缺乏活力（87.5±11.7%）几乎以相同的频率记录疲劳(75.0±15. 3%），记忆障碍（62.5±17.1%），其频率超过 SAS 患者平均值的 1.5-3 倍。高 CVR 和 SAS 虚弱亚抑郁变异型患者最常见的是：头晕（83.3±15.2）、睡眠障碍和不安睡眠（66.7±19.2%）、敏感和痛苦（66.7±19.2%）。结论 根据高 CVR 患者的 SAS 变异，对症状进行了排序，并定义了主要综合征。